Reduced cellularity of bone marrow in multiple sclerosis with decreased MSC expansion potential and premature ageing in vitro

• Published in: Multiple sclerosis Vol. 24; no. 7; pp. 919 - 931
• Main Authors: Redondo, Juliana, Sarkar, Pamela, Kemp, Kevin, Virgo, Paul F, Pawade, Joya, Norton, Aimie, Emery, David C, Guttridge, Martin G, Marks, David I, Wilkins, Alastair, Scolding, Neil J, Rice, Claire M
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.06.2018
• Subjects: Adult; Cell Proliferation - physiology; Cells, Cultured; Cellular Senescence - physiology; Female; Humans; Male; Mesenchymal Stem Cells - pathology; Middle Aged; Multiple Sclerosis - pathology; Stem Cell Niche - physiology; Cell therapy; mesenchymal stromal cell; multiple sclerosis; bone marrow

Background: Autologous bone-marrow-derived cells are currently employed in clinical studies of cell-based therapy in multiple sclerosis (MS) although the bone marrow microenvironment and marrow-derived cells isolated from patients with MS have not been extensively characterised. Objectives: To exami...