Exercise tolerance in obstructive sleep apnea-hypopnea (OSAH), before and after CPAP treatment: Effects of autonomic dysfunction improvement

• Published in: Respiratory physiology & neurobiology Vol. 236; pp. 51 - 56
• Main Authors: Quadri, F., Boni, E., Pini, L., Bottone, D., Venturoli, N., Corda, L., Tantucci, C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2017
• Subjects: Adult; Aged; Autonomic assessment; Autonomic Nervous System Diseases - etiology; Autonomic Nervous System Diseases - therapy; Cardio-pulmonary exercise test (CPET); Continuous Positive Airway Pressure - methods; CPAP; Electrocardiography; Exercise Tolerance - physiology; Female; Hand Strength - physiology; Heart Rate - physiology; Humans; Male; Medical Education; Middle Aged; Obstructive sleep apnea hypopnea; Oxygen Consumption - physiology; Pulmonary/Respiratory; Sleep Apnea, Obstructive - complications; Sleep Apnea, Obstructive - therapy; Sleep study; Tilt-Table Test; Valsalva Maneuver - physiology; Sleep study; Autonomic assessment; CPAP; Cardio-pulmonary exercise test (CPET); Obstructive sleep apnea hypopnea

•OSAH is associated with reduced exercise tolerance and autonomic abnormalities.•Patients have been treated with CPAP for 2 months.•CPAP reduces heart rate variability and increases maximal workload and VO2peak.•CPAP reduces sympathetic hyperactivity causing better tolerance to the effort. Obstructi...