Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications

• Published in: Frontiers in oncology Vol. 11; p. 652266
• Main Authors: Zhang, Ying, Zhang, Hongyi, Wang, Minghong, Schmid, Thomas, Xin, Zhaochen, Kozhuharova, Lora, Yu, Wai-Kin, Huang, Yuan, Cai, Fengfeng, Biskup, Ewelina
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.03.2021
• Subjects: biomarkers; breast cancer; hypoxia; hypoxia-induced factors; hypoxia-related treatment; Oncology; oxidative stress; hypoxia; biomarkers; hypoxia-related treatment; breast cancer; precision medicine; hypoxia-induced factors; oxidative stress

Breast cancer has been the leading cause of female cancer deaths for decades. Intratumoral hypoxia, mainly caused by structural and functional abnormalities in microvasculature, is often associated with a more aggressive phenotype, increased risk of metastasis and resistance to anti-malignancy treat...