The prognostic value of temporal in vitro and in vivo derived hypoxia gene-expression signatures in breast cancer

• Published in: Radiotherapy and oncology Vol. 102; no. 3; pp. 436 - 443
• Main Authors: Starmans, Maud H.W, Chu, Kenneth C, Haider, Syed, Nguyen, Francis, Seigneuric, Renaud, Magagnin, Michael G, Koritzinsky, Marianne, Kasprzyk, Arek, Boutros, Paul C, Wouters, Bradly G, Lambin, Philippe
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.03.2012
• Subjects: Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Cell Line, Tumor; Female; Gene Expression Profiling; Hematology, Oncology and Palliative Medicine; Humans; Hypoxia; Hypoxia - metabolism; Microarray; Princess Margaret Hospital; Principal Component Analysis; Prognosis; Prognostic marker; Hypoxia; Princess Margaret Hospital; Microarray; Gene-expression profiling; Prognostic marker

Abstract Background and purpose Recent data suggest that in vitro and in vivo derived hypoxia gene-expression signatures have prognostic power in breast and possibly other cancers. However, both tumour hypoxia and the biological adaptation to this stress are highly dynamic. Assessment of time-depend...