Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1–Deficient Mice

• Published in: Journal of investigative dermatology Vol. 140; no. 2; pp. 298 - 308.e5
• Main Authors: Atsugi, Toru, Yokouchi, Mariko, Hirano, Takashige, Hirabayashi, Ai, Nagai, Toshihiro, Ohyama, Manabu, Abe, Takaya, Kaneko, Mari, Zouboulis, Christos C., Amagai, Masayuki, Kubo, Akiharu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.02.2020
• Subjects: NHK; SC; 3D; KO; scFv; cKO; TJ; Dsg1; TEER

Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine gl...