Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1–Deficient Mice

Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine gl...

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Published inJournal of investigative dermatology Vol. 140; no. 2; pp. 298 - 308.e5
Main Authors Atsugi, Toru, Yokouchi, Mariko, Hirano, Takashige, Hirabayashi, Ai, Nagai, Toshihiro, Ohyama, Manabu, Abe, Takaya, Kaneko, Mari, Zouboulis, Christos C., Amagai, Masayuki, Kubo, Akiharu
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LanguageEnglish
Published United States Elsevier Inc 01.02.2020
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Abstract Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine glands of mammals, exhibit a form of polarized stratified epithelium equipped with tight junctions (TJs), and found that holocrine secretion occurred outside the TJ barriers. Sebaceous glands share characteristics of stratified epithelia with interfollicular epidermis, including basal-layer–restricted cell proliferation, TJ barrier formation at a specific single layer of cells with apico-basolateral plasma membrane polarity, and cell death outside the TJ barrier. Knockout of claudin-1, a transmembrane adhesive protein in TJs, in mice caused leakage of the TJ barrier in sebaceous glands and incomplete degradation of the plasma membrane and nuclei during holocrine secretion. Claudin-1 knockout resulted in the accumulation of incompletely degenerated sebocytes in sebaceous ducts, suggesting that the TJ barrier was necessary for differentiation of holocrine secretion. The redefinition of sebaceous glands as TJ-forming stratified epithelia provides an important framework to understand the molecular mechanism of holocrine secretion. [Display omitted]
AbstractList Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine glands of mammals, exhibit a form of polarized stratified epithelium equipped with tight junctions (TJs), and found that holocrine secretion occurred outside the TJ barriers. Sebaceous glands share characteristics of stratified epithelia with interfollicular epidermis, including basal-layer-restricted cell proliferation, TJ barrier formation at a specific single layer of cells with apico-basolateral plasma membrane polarity, and cell death outside the TJ barrier. Knockout of claudin-1, a transmembrane adhesive protein in TJs, in mice caused leakage of the TJ barrier in sebaceous glands and incomplete degradation of the plasma membrane and nuclei during holocrine secretion. Claudin-1 knockout resulted in the accumulation of incompletely degenerated sebocytes in sebaceous ducts, suggesting that the TJ barrier was necessary for differentiation of holocrine secretion. The redefinition of sebaceous glands as TJ-forming stratified epithelia provides an important framework to understand the molecular mechanism of holocrine secretion.
Holocrine secretion is a specific mode of secretion involving secretion of entire cytoplasmic materials with remnants of dead cells, as observed in multicellular exocrine glands of reptiles, birds, and mammals. Here, we found that sebaceous glands in mice, representative of multicellular exocrine glands of mammals, exhibit a form of polarized stratified epithelium equipped with tight junctions (TJs), and found that holocrine secretion occurred outside the TJ barriers. Sebaceous glands share characteristics of stratified epithelia with interfollicular epidermis, including basal-layer–restricted cell proliferation, TJ barrier formation at a specific single layer of cells with apico-basolateral plasma membrane polarity, and cell death outside the TJ barrier. Knockout of claudin-1, a transmembrane adhesive protein in TJs, in mice caused leakage of the TJ barrier in sebaceous glands and incomplete degradation of the plasma membrane and nuclei during holocrine secretion. Claudin-1 knockout resulted in the accumulation of incompletely degenerated sebocytes in sebaceous ducts, suggesting that the TJ barrier was necessary for differentiation of holocrine secretion. The redefinition of sebaceous glands as TJ-forming stratified epithelia provides an important framework to understand the molecular mechanism of holocrine secretion. [Display omitted]
Author Nagai, Toshihiro
Kubo, Akiharu
Hirabayashi, Ai
Abe, Takaya
Zouboulis, Christos C.
Ohyama, Manabu
Hirano, Takashige
Atsugi, Toru
Yokouchi, Mariko
Amagai, Masayuki
Kaneko, Mari
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Cites_doi 10.1369/jhc.6A6944.2006
10.1083/jcb.200510043
10.1016/j.exger.2008.09.001
10.1152/ajprenal.00450.2009
10.1177/30.12.6185564
10.1016/j.jdermsci.2013.01.002
10.1136/gutjnl-2014-308419
10.1002/aja.1001620406
10.1242/jcs.02406
10.1083/jcb.200110122
10.1016/j.semcdb.2012.08.010
10.1111/1523-1747.ep12292052
10.1371/journal.pone.0161759
10.1038/sj.jid.5701132
10.1016/j.jdermsci.2014.11.007
10.1038/jid.2011.435
10.1152/physrev.00019.2012
10.1083/jcb.115.5.1449
10.1016/S0002-9440(10)62370-X
10.1016/j.ydbio.2011.12.028
10.1046/j.1523-1747.1999.00740.x
10.1634/stemcells.2007-0651
10.1111/j.1365-2133.1984.tb04684.x
10.1242/dev.129.7.1775
10.1136/jcp.55.10.763
10.1046/j.1523-1747.1999.00771.x
10.1073/pnas.96.15.8551
10.1038/jid.1962.60
10.1016/j.jdermsci.2013.04.021
10.1074/jbc.M608853200
10.1172/JCI57416
10.1016/j.jid.2016.10.017
10.1016/j.jaci.2016.07.003
10.1152/ajprenal.00384.2003
10.1078/0171-9335-00244
10.1016/S0955-0674(02)00362-9
10.1038/jid.2014.293
10.1159/000017861
10.7554/eLife.19593
10.1159/000441541
10.1084/jem.20091527
10.1016/j.jdermsci.2012.11.595
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References Kitson, van Lennep (bib19) 1984; 110
Vasioukhin, Degenstein, Wise, Fuchs (bib36) 1999; 96
Zouboulis, Xia, Akamatsu, Seltmann, Fritsch, Hornemann (bib45) 1998; 196
Turksen, Troy (bib35) 2002; 129
Yuki, Tobiishi, Kusaka-Kikushima, Ota, Tokura (bib42) 2016; 11
Brandner, Kief, Grund, Rendl, Houdek, Kuhn (bib4) 2002; 81
De Benedetto, Kubo, Beck (bib6) 2012; 132
Yokouchi, Kubo, Kawasaki, Yoshida, Ishii, Furuse (bib39) 2015; 77
Günzel, Yu (bib11) 2013; 93
Frances, Niemann (bib8) 2012; 363
Yoshida, Yokouchi, Nagao, Ishii, Amagai, Kubo (bib40) 2013; 71
Quay (bib27) 1984
Niemann, Horsley (bib25) 2012; 23
Tanaka, Takechi, Kiyonari, Shioi, Tamura, Tsukita (bib32) 2015; 64
Xian, Wawrzyniak, Rückert, Duan, Meng, Sokolowska (bib37) 2016; 138
Li, Huey, Yu (bib22) 2004; 286
Brandner (bib3) 2016; 49
Kubo, Nagao, Amagai (bib20) 2012; 122
McBride, Leonard, Reynolds (bib24) 2002; 55
Smalley, Brafford, Haass, Brandner, Brown, Herlyn (bib30) 2005; 166
Tatum, Zhang, Salleng, Lu, Lin, Lu (bib33) 2010; 298
Briggman, Bank, Bigelow, Graves, Spicer (bib5) 1981; 162
Ikenouchi, Furuse, Furuse, Sasaki, Tsukita, Tsukita (bib15) 2005; 171
Tsukita, Furuse (bib34) 2002; 14
Bell (bib2) 1984
Fujita, Chiba, Yokozaki, Sakai, Sugimoto, Wada (bib9) 2006; 54
Lo Celso, Berta, Braun, Frye, Lyle, Zouboulis (bib23) 2008; 26
Alexandre, Lu, Chen (bib1) 2005; 118
Hou, Gomes, Paul, Goodenough (bib14) 2006; 281
Yuki, Komiya, Kusaka, Kuze, Sugiyama, Inoue (bib41) 2013; 69
Zouboulis, Adjaye, Akamatsu, Moe-Behrens, Niemann (bib43) 2008; 43
Furuse, Hata, Furuse, Yoshida, Haratake, Sugitani (bib10) 2002; 156
Ishii, Lin, Siegel, Stanley (bib16) 2008; 128
Yokouchi, Atsugi, Logtestijn, Tanaka, Kajimura, Suematsu (bib38) 2016; 5
Hashimoto (bib12) 1971; 57
Fischer, Fumicz, Rossiter, Napirei, Buchberger, Tschachler (bib7) 2017; 137
Kubo, Nagao, Yokouchi, Sasaki, Amagai (bib21) 2009; 206
Paus, Müller-Röver, Van Der Veen, Maurer, Eichmüller, Ling (bib26) 1999; 113
Zouboulis, Seltmann, Neitzel, Orfanos (bib44) 1999; 113
Hibbs (bib13) 1962; 38
Itoh, Yonemura, Nagafuchi, Tsukita, Tsukita (bib17) 1991; 115
Sugawara, Iwamoto, Akashi, Kojima, Hisatsune, Sugai (bib31) 2013; 70
Jung, Tam, Ray Jalian, Rox Anderson, Evans (bib18) 2015; 135
Saitou, Ando-Akatsuka, Itoh, Furuse, Inazawa, Fujimoto (bib28) 1997; 73
Shaklai, Tavassoli (bib29) 1982; 30
Shaklai (10.1016/j.jid.2019.06.150_bib29) 1982; 30
Lo Celso (10.1016/j.jid.2019.06.150_bib23) 2008; 26
Smalley (10.1016/j.jid.2019.06.150_bib30) 2005; 166
Yuki (10.1016/j.jid.2019.06.150_bib41) 2013; 69
Briggman (10.1016/j.jid.2019.06.150_bib5) 1981; 162
Fujita (10.1016/j.jid.2019.06.150_bib9) 2006; 54
Frances (10.1016/j.jid.2019.06.150_bib8) 2012; 363
Yokouchi (10.1016/j.jid.2019.06.150_bib39) 2015; 77
Kubo (10.1016/j.jid.2019.06.150_bib20) 2012; 122
Zouboulis (10.1016/j.jid.2019.06.150_bib44) 1999; 113
Tsukita (10.1016/j.jid.2019.06.150_bib34) 2002; 14
De Benedetto (10.1016/j.jid.2019.06.150_bib6) 2012; 132
Hibbs (10.1016/j.jid.2019.06.150_bib13) 1962; 38
Itoh (10.1016/j.jid.2019.06.150_bib17) 1991; 115
Jung (10.1016/j.jid.2019.06.150_bib18) 2015; 135
Furuse (10.1016/j.jid.2019.06.150_bib46) 2002; 156
Hashimoto (10.1016/j.jid.2019.06.150_bib12) 1971; 57
Yokouchi (10.1016/j.jid.2019.06.150_bib52) 2015; 77
Furuse (10.1016/j.jid.2019.06.150_bib10) 2002; 156
Tatum (10.1016/j.jid.2019.06.150_bib33) 2010; 298
Saitou (10.1016/j.jid.2019.06.150_bib50) 1997; 73
Bell (10.1016/j.jid.2019.06.150_bib2) 1984
Ikenouchi (10.1016/j.jid.2019.06.150_bib47) 2005; 171
Saitou (10.1016/j.jid.2019.06.150_bib28) 1997; 73
Zouboulis (10.1016/j.jid.2019.06.150_bib43) 2008; 43
Vasioukhin (10.1016/j.jid.2019.06.150_bib51) 1999; 96
Ikenouchi (10.1016/j.jid.2019.06.150_bib15) 2005; 171
Kitson (10.1016/j.jid.2019.06.150_bib19) 1984; 110
Günzel (10.1016/j.jid.2019.06.150_bib11) 2013; 93
Turksen (10.1016/j.jid.2019.06.150_bib35) 2002; 129
Vasioukhin (10.1016/j.jid.2019.06.150_bib36) 1999; 96
Zouboulis (10.1016/j.jid.2019.06.150_bib53) 1999; 113
Brandner (10.1016/j.jid.2019.06.150_bib4) 2002; 81
Niemann (10.1016/j.jid.2019.06.150_bib25) 2012; 23
Alexandre (10.1016/j.jid.2019.06.150_bib1) 2005; 118
Xian (10.1016/j.jid.2019.06.150_bib37) 2016; 138
Itoh (10.1016/j.jid.2019.06.150_bib49) 1991; 115
Ishii (10.1016/j.jid.2019.06.150_bib16) 2008; 128
Yoshida (10.1016/j.jid.2019.06.150_bib40) 2013; 71
Zouboulis (10.1016/j.jid.2019.06.150_bib45) 1998; 196
Kubo (10.1016/j.jid.2019.06.150_bib21) 2009; 206
Sugawara (10.1016/j.jid.2019.06.150_bib31) 2013; 70
Yuki (10.1016/j.jid.2019.06.150_bib42) 2016; 11
Brandner (10.1016/j.jid.2019.06.150_bib3) 2016; 49
Ishii (10.1016/j.jid.2019.06.150_bib48) 2008; 128
McBride (10.1016/j.jid.2019.06.150_bib24) 2002; 55
Tanaka (10.1016/j.jid.2019.06.150_bib32) 2015; 64
Hou (10.1016/j.jid.2019.06.150_bib14) 2006; 281
Quay (10.1016/j.jid.2019.06.150_bib27) 1984
Yokouchi (10.1016/j.jid.2019.06.150_bib38) 2016; 5
Fischer (10.1016/j.jid.2019.06.150_bib7) 2017; 137
Li (10.1016/j.jid.2019.06.150_bib22) 2004; 286
Paus (10.1016/j.jid.2019.06.150_bib26) 1999; 113
References_xml – volume: 57
  start-page: 17
  year: 1971
  end-page: 31
  ident: bib12
  article-title: Intercellular spaces of the human epidermis as demonstrated with lanthanum
  publication-title: J Invest Dermatol
  contributor:
    fullname: Hashimoto
– volume: 70
  start-page: 12
  year: 2013
  end-page: 18
  ident: bib31
  article-title: Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice
  publication-title: J Dermatol Sci
  contributor:
    fullname: Sugai
– volume: 26
  start-page: 1241
  year: 2008
  end-page: 1252
  ident: bib23
  article-title: Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
  publication-title: Stem Cells
  contributor:
    fullname: Zouboulis
– volume: 113
  start-page: 523
  year: 1999
  end-page: 532
  ident: bib26
  article-title: A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
  publication-title: J Invest Dermatol
  contributor:
    fullname: Ling
– volume: 30
  start-page: 1325
  year: 1982
  end-page: 1330
  ident: bib29
  article-title: Lanthanum as an electron microscopic stain
  publication-title: J Histochem Cytochem
  contributor:
    fullname: Tavassoli
– volume: 122
  start-page: 440
  year: 2012
  end-page: 447
  ident: bib20
  article-title: Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
  publication-title: J Clin Invest
  contributor:
    fullname: Amagai
– volume: 128
  start-page: 939
  year: 2008
  end-page: 948
  ident: bib16
  article-title: Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies
  publication-title: J Invest Dermatol
  contributor:
    fullname: Stanley
– volume: 196
  start-page: 21
  year: 1998
  end-page: 31
  ident: bib45
  article-title: The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
  publication-title: Dermatology
  contributor:
    fullname: Hornemann
– volume: 54
  start-page: 933
  year: 2006
  end-page: 944
  ident: bib9
  article-title: Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine
  publication-title: J Histochem Cytochem
  contributor:
    fullname: Wada
– volume: 55
  start-page: 763
  year: 2002
  end-page: 766
  ident: bib24
  article-title: Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma
  publication-title: J Clin Pathol
  contributor:
    fullname: Reynolds
– volume: 118
  start-page: 2683
  year: 2005
  end-page: 2693
  ident: bib1
  article-title: Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cells
  publication-title: J Cell Sci
  contributor:
    fullname: Chen
– volume: 73
  start-page: 222
  year: 1997
  end-page: 231
  ident: bib28
  article-title: Mammalian occludin in epithelial cells: its expression and subcellular distribution
  publication-title: Eur J Cell Biol
  contributor:
    fullname: Fujimoto
– volume: 110
  start-page: 601
  year: 1984
  end-page: 606
  ident: bib19
  article-title: Intercellular junctions and the permeability barrier in human sebaceous glands
  publication-title: Br J Dermatol
  contributor:
    fullname: van Lennep
– volume: 64
  start-page: 1529
  year: 2015
  end-page: 1538
  ident: bib32
  article-title: Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice
  publication-title: Gut
  contributor:
    fullname: Tsukita
– volume: 138
  start-page: 890
  year: 2016
  end-page: 893.e9
  ident: bib37
  article-title: Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes
  publication-title: J Allergy Clin Immunol
  contributor:
    fullname: Sokolowska
– volume: 113
  start-page: 1011
  year: 1999
  end-page: 1020
  ident: bib44
  article-title: Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
  publication-title: J Invest Dermatol
  contributor:
    fullname: Orfanos
– volume: 77
  start-page: 28
  year: 2015
  end-page: 36
  ident: bib39
  article-title: Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum
  publication-title: J Dermatol Sci
  contributor:
    fullname: Furuse
– volume: 135
  start-page: 39
  year: 2015
  end-page: 44
  ident: bib18
  article-title: Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy
  publication-title: J Invest Dermatol
  contributor:
    fullname: Evans
– volume: 5
  year: 2016
  ident: bib38
  article-title: Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape
  publication-title: ELife
  contributor:
    fullname: Suematsu
– volume: 81
  start-page: 253
  year: 2002
  end-page: 263
  ident: bib4
  article-title: Organization and formation of the tight junction system in human epidermis and cultured keratinocytes
  publication-title: Eur J Cell Biol
  contributor:
    fullname: Kuhn
– volume: 38
  start-page: 329
  year: 1962
  end-page: 336
  ident: bib13
  article-title: Electron microscopy of human axillary sebaceous glands
  publication-title: J Invest Dermatol
  contributor:
    fullname: Hibbs
– volume: 171
  start-page: 939
  year: 2005
  end-page: 945
  ident: bib15
  article-title: Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
  publication-title: J Cell Biol
  contributor:
    fullname: Tsukita
– volume: 49
  start-page: 27
  year: 2016
  end-page: 37
  ident: bib3
  article-title: Importance of tight junctions in relation to skin barrier function
  publication-title: Curr Probl Dermatol
  contributor:
    fullname: Brandner
– volume: 93
  start-page: 525
  year: 2013
  end-page: 569
  ident: bib11
  article-title: Claudins and the modulation of tight junction permeability
  publication-title: Physiol Rev
  contributor:
    fullname: Yu
– volume: 71
  start-page: 89
  year: 2013
  end-page: 99
  ident: bib40
  article-title: Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis
  publication-title: J Dermatol Sci
  contributor:
    fullname: Kubo
– volume: 43
  start-page: 986
  year: 2008
  end-page: 997
  ident: bib43
  article-title: Human skin stem cells and the ageing process
  publication-title: Exp Gerontol
  contributor:
    fullname: Niemann
– volume: 96
  start-page: 8551
  year: 1999
  end-page: 8556
  ident: bib36
  article-title: The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
  publication-title: Proc Natl Acad Sci USA
  contributor:
    fullname: Fuchs
– volume: 156
  start-page: 1099
  year: 2002
  end-page: 1111
  ident: bib10
  article-title: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
  publication-title: J Cell Biol
  contributor:
    fullname: Sugitani
– volume: 137
  start-page: 587
  year: 2017
  end-page: 594
  ident: bib7
  article-title: Holocrine secretion of sebum is a unique DNase2-dependent mode of programmed cell death
  publication-title: J Invest Dermatol
  contributor:
    fullname: Tschachler
– start-page: 248
  year: 1984
  end-page: 254
  ident: bib27
  article-title: Uropygial gland
  publication-title: Biology of the integument;2: Vertebrates. 2
  contributor:
    fullname: Quay
– start-page: 318
  year: 1984
  end-page: 338
  ident: bib2
  article-title: Sebaceous glands
  publication-title: Biology of the integument;2: Vertebrates. 2
  contributor:
    fullname: Bell
– volume: 206
  start-page: 2937
  year: 2009
  end-page: 2946
  ident: bib21
  article-title: External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
  publication-title: J Exp Med
  contributor:
    fullname: Amagai
– volume: 286
  start-page: F1063
  year: 2004
  end-page: F1071
  ident: bib22
  article-title: Expression of claudin-7 and -8 along the mouse nephron
  publication-title: Am J Physiol Renal Physiol
  contributor:
    fullname: Yu
– volume: 23
  start-page: 928
  year: 2012
  end-page: 936
  ident: bib25
  article-title: Development and homeostasis of the sebaceous gland
  publication-title: Semin Cell Dev Biol
  contributor:
    fullname: Horsley
– volume: 132
  start-page: 949
  year: 2012
  end-page: 963
  ident: bib6
  article-title: Skin barrier disruption: A requirement for allergen sensitization?
  publication-title: J Invest Dermatol
  contributor:
    fullname: Beck
– volume: 162
  start-page: 357
  year: 1981
  end-page: 368
  ident: bib5
  article-title: Structure of the tight junctions of the human eccrine sweat gland
  publication-title: Am J Anat
  contributor:
    fullname: Spicer
– volume: 363
  start-page: 138
  year: 2012
  end-page: 146
  ident: bib8
  article-title: Stem cell dynamics in sebaceous gland morphogenesis in mouse skin
  publication-title: Dev Biol
  contributor:
    fullname: Niemann
– volume: 115
  start-page: 1449
  year: 1991
  end-page: 1462
  ident: bib17
  article-title: A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites
  publication-title: J Cell Biol
  contributor:
    fullname: Tsukita
– volume: 129
  start-page: 1775
  year: 2002
  end-page: 1784
  ident: bib35
  article-title: Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
  publication-title: Development
  contributor:
    fullname: Troy
– volume: 11
  start-page: e0161759
  year: 2016
  ident: bib42
  article-title: Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17
  publication-title: PLOS ONE
  contributor:
    fullname: Tokura
– volume: 166
  start-page: 1541
  year: 2005
  end-page: 1554
  ident: bib30
  article-title: Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion
  publication-title: Am J Pathol
  contributor:
    fullname: Herlyn
– volume: 14
  start-page: 531
  year: 2002
  end-page: 536
  ident: bib34
  article-title: Claudin-based barrier in simple and stratified cellular sheets
  publication-title: Curr Opin Cell Biol
  contributor:
    fullname: Furuse
– volume: 69
  start-page: 148
  year: 2013
  end-page: 158
  ident: bib41
  article-title: Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing
  publication-title: J Dermatol Sci
  contributor:
    fullname: Inoue
– volume: 281
  start-page: 36117
  year: 2006
  end-page: 36123
  ident: bib14
  article-title: Study of claudin function by RNA interference
  publication-title: J Biol Chem
  contributor:
    fullname: Goodenough
– volume: 298
  start-page: F24
  year: 2010
  end-page: F34
  ident: bib33
  article-title: Renal salt wasting and chronic dehydration in claudin-7-deficient mice
  publication-title: Am J Physiol Renal Physiol
  contributor:
    fullname: Lu
– volume: 54
  start-page: 933
  year: 2006
  ident: 10.1016/j.jid.2019.06.150_bib9
  article-title: Differential expression and subcellular localization of claudin-7, -8, -12, -13, and -15 along the mouse intestine
  publication-title: J Histochem Cytochem
  doi: 10.1369/jhc.6A6944.2006
  contributor:
    fullname: Fujita
– volume: 171
  start-page: 939
  year: 2005
  ident: 10.1016/j.jid.2019.06.150_bib15
  article-title: Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200510043
  contributor:
    fullname: Ikenouchi
– volume: 43
  start-page: 986
  year: 2008
  ident: 10.1016/j.jid.2019.06.150_bib43
  article-title: Human skin stem cells and the ageing process
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2008.09.001
  contributor:
    fullname: Zouboulis
– volume: 73
  start-page: 222
  year: 1997
  ident: 10.1016/j.jid.2019.06.150_bib50
  article-title: Mammalian occludin in epithelial cells: its expression and subcellular distribution
  publication-title: Eur J Cell Biol
  contributor:
    fullname: Saitou
– volume: 298
  start-page: F24
  year: 2010
  ident: 10.1016/j.jid.2019.06.150_bib33
  article-title: Renal salt wasting and chronic dehydration in claudin-7-deficient mice
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00450.2009
  contributor:
    fullname: Tatum
– volume: 30
  start-page: 1325
  year: 1982
  ident: 10.1016/j.jid.2019.06.150_bib29
  article-title: Lanthanum as an electron microscopic stain
  publication-title: J Histochem Cytochem
  doi: 10.1177/30.12.6185564
  contributor:
    fullname: Shaklai
– volume: 70
  start-page: 12
  year: 2013
  ident: 10.1016/j.jid.2019.06.150_bib31
  article-title: Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2013.01.002
  contributor:
    fullname: Sugawara
– volume: 64
  start-page: 1529
  year: 2015
  ident: 10.1016/j.jid.2019.06.150_bib32
  article-title: Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice
  publication-title: Gut
  doi: 10.1136/gutjnl-2014-308419
  contributor:
    fullname: Tanaka
– volume: 162
  start-page: 357
  year: 1981
  ident: 10.1016/j.jid.2019.06.150_bib5
  article-title: Structure of the tight junctions of the human eccrine sweat gland
  publication-title: Am J Anat
  doi: 10.1002/aja.1001620406
  contributor:
    fullname: Briggman
– volume: 118
  start-page: 2683
  year: 2005
  ident: 10.1016/j.jid.2019.06.150_bib1
  article-title: Overexpression of claudin-7 decreases the paracellular Cl- conductance and increases the paracellular Na+ conductance in LLC-PK1 cells
  publication-title: J Cell Sci
  doi: 10.1242/jcs.02406
  contributor:
    fullname: Alexandre
– volume: 156
  start-page: 1099
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib10
  article-title: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200110122
  contributor:
    fullname: Furuse
– volume: 23
  start-page: 928
  year: 2012
  ident: 10.1016/j.jid.2019.06.150_bib25
  article-title: Development and homeostasis of the sebaceous gland
  publication-title: Semin Cell Dev Biol
  doi: 10.1016/j.semcdb.2012.08.010
  contributor:
    fullname: Niemann
– volume: 57
  start-page: 17
  year: 1971
  ident: 10.1016/j.jid.2019.06.150_bib12
  article-title: Intercellular spaces of the human epidermis as demonstrated with lanthanum
  publication-title: J Invest Dermatol
  doi: 10.1111/1523-1747.ep12292052
  contributor:
    fullname: Hashimoto
– volume: 11
  start-page: e0161759
  year: 2016
  ident: 10.1016/j.jid.2019.06.150_bib42
  article-title: Impaired tight junctions in atopic dermatitis skin and in a skin-equivalent model treated with interleukin-17
  publication-title: PLOS ONE
  doi: 10.1371/journal.pone.0161759
  contributor:
    fullname: Yuki
– volume: 128
  start-page: 939
  year: 2008
  ident: 10.1016/j.jid.2019.06.150_bib48
  article-title: Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies
  publication-title: J Invest Dermatol
  doi: 10.1038/sj.jid.5701132
  contributor:
    fullname: Ishii
– volume: 77
  start-page: 28
  year: 2015
  ident: 10.1016/j.jid.2019.06.150_bib39
  article-title: Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2014.11.007
  contributor:
    fullname: Yokouchi
– volume: 132
  start-page: 949
  year: 2012
  ident: 10.1016/j.jid.2019.06.150_bib6
  article-title: Skin barrier disruption: A requirement for allergen sensitization?
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2011.435
  contributor:
    fullname: De Benedetto
– volume: 93
  start-page: 525
  year: 2013
  ident: 10.1016/j.jid.2019.06.150_bib11
  article-title: Claudins and the modulation of tight junction permeability
  publication-title: Physiol Rev
  doi: 10.1152/physrev.00019.2012
  contributor:
    fullname: Günzel
– volume: 115
  start-page: 1449
  year: 1991
  ident: 10.1016/j.jid.2019.06.150_bib17
  article-title: A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites
  publication-title: J Cell Biol
  doi: 10.1083/jcb.115.5.1449
  contributor:
    fullname: Itoh
– volume: 166
  start-page: 1541
  year: 2005
  ident: 10.1016/j.jid.2019.06.150_bib30
  article-title: Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion
  publication-title: Am J Pathol
  doi: 10.1016/S0002-9440(10)62370-X
  contributor:
    fullname: Smalley
– volume: 363
  start-page: 138
  year: 2012
  ident: 10.1016/j.jid.2019.06.150_bib8
  article-title: Stem cell dynamics in sebaceous gland morphogenesis in mouse skin
  publication-title: Dev Biol
  doi: 10.1016/j.ydbio.2011.12.028
  contributor:
    fullname: Frances
– volume: 113
  start-page: 523
  year: 1999
  ident: 10.1016/j.jid.2019.06.150_bib26
  article-title: A comprehensive guide for the recognition and classification of distinct stages of hair follicle morphogenesis
  publication-title: J Invest Dermatol
  doi: 10.1046/j.1523-1747.1999.00740.x
  contributor:
    fullname: Paus
– volume: 26
  start-page: 1241
  year: 2008
  ident: 10.1016/j.jid.2019.06.150_bib23
  article-title: Characterization of bipotential epidermal progenitors derived from human sebaceous gland: contrasting roles of c-Myc and beta-catenin
  publication-title: Stem Cells
  doi: 10.1634/stemcells.2007-0651
  contributor:
    fullname: Lo Celso
– volume: 110
  start-page: 601
  year: 1984
  ident: 10.1016/j.jid.2019.06.150_bib19
  article-title: Intercellular junctions and the permeability barrier in human sebaceous glands
  publication-title: Br J Dermatol
  doi: 10.1111/j.1365-2133.1984.tb04684.x
  contributor:
    fullname: Kitson
– start-page: 248
  year: 1984
  ident: 10.1016/j.jid.2019.06.150_bib27
  article-title: Uropygial gland
  contributor:
    fullname: Quay
– volume: 171
  start-page: 939
  year: 2005
  ident: 10.1016/j.jid.2019.06.150_bib47
  article-title: Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200510043
  contributor:
    fullname: Ikenouchi
– volume: 129
  start-page: 1775
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib35
  article-title: Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
  publication-title: Development
  doi: 10.1242/dev.129.7.1775
  contributor:
    fullname: Turksen
– volume: 55
  start-page: 763
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib24
  article-title: Loss of p21(WAF1) compartmentalisation in sebaceous carcinoma compared with sebaceous hyperplasia and sebaceous adenoma
  publication-title: J Clin Pathol
  doi: 10.1136/jcp.55.10.763
  contributor:
    fullname: McBride
– start-page: 318
  year: 1984
  ident: 10.1016/j.jid.2019.06.150_bib2
  article-title: Sebaceous glands
  contributor:
    fullname: Bell
– volume: 113
  start-page: 1011
  year: 1999
  ident: 10.1016/j.jid.2019.06.150_bib44
  article-title: Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
  publication-title: J Invest Dermatol
  doi: 10.1046/j.1523-1747.1999.00771.x
  contributor:
    fullname: Zouboulis
– volume: 96
  start-page: 8551
  year: 1999
  ident: 10.1016/j.jid.2019.06.150_bib36
  article-title: The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.96.15.8551
  contributor:
    fullname: Vasioukhin
– volume: 128
  start-page: 939
  year: 2008
  ident: 10.1016/j.jid.2019.06.150_bib16
  article-title: Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies
  publication-title: J Invest Dermatol
  doi: 10.1038/sj.jid.5701132
  contributor:
    fullname: Ishii
– volume: 38
  start-page: 329
  year: 1962
  ident: 10.1016/j.jid.2019.06.150_bib13
  article-title: Electron microscopy of human axillary sebaceous glands
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.1962.60
  contributor:
    fullname: Hibbs
– volume: 71
  start-page: 89
  year: 2013
  ident: 10.1016/j.jid.2019.06.150_bib40
  article-title: Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2013.04.021
  contributor:
    fullname: Yoshida
– volume: 281
  start-page: 36117
  year: 2006
  ident: 10.1016/j.jid.2019.06.150_bib14
  article-title: Study of claudin function by RNA interference
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M608853200
  contributor:
    fullname: Hou
– volume: 122
  start-page: 440
  year: 2012
  ident: 10.1016/j.jid.2019.06.150_bib20
  article-title: Epidermal barrier dysfunction and cutaneous sensitization in atopic diseases
  publication-title: J Clin Invest
  doi: 10.1172/JCI57416
  contributor:
    fullname: Kubo
– volume: 96
  start-page: 8551
  year: 1999
  ident: 10.1016/j.jid.2019.06.150_bib51
  article-title: The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.96.15.8551
  contributor:
    fullname: Vasioukhin
– volume: 137
  start-page: 587
  year: 2017
  ident: 10.1016/j.jid.2019.06.150_bib7
  article-title: Holocrine secretion of sebum is a unique DNase2-dependent mode of programmed cell death
  publication-title: J Invest Dermatol
  doi: 10.1016/j.jid.2016.10.017
  contributor:
    fullname: Fischer
– volume: 73
  start-page: 222
  year: 1997
  ident: 10.1016/j.jid.2019.06.150_bib28
  article-title: Mammalian occludin in epithelial cells: its expression and subcellular distribution
  publication-title: Eur J Cell Biol
  contributor:
    fullname: Saitou
– volume: 138
  start-page: 890
  year: 2016
  ident: 10.1016/j.jid.2019.06.150_bib37
  article-title: Anionic surfactants and commercial detergents decrease tight junction barrier integrity in human keratinocytes
  publication-title: J Allergy Clin Immunol
  doi: 10.1016/j.jaci.2016.07.003
  contributor:
    fullname: Xian
– volume: 286
  start-page: F1063
  year: 2004
  ident: 10.1016/j.jid.2019.06.150_bib22
  article-title: Expression of claudin-7 and -8 along the mouse nephron
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00384.2003
  contributor:
    fullname: Li
– volume: 81
  start-page: 253
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib4
  article-title: Organization and formation of the tight junction system in human epidermis and cultured keratinocytes
  publication-title: Eur J Cell Biol
  doi: 10.1078/0171-9335-00244
  contributor:
    fullname: Brandner
– volume: 14
  start-page: 531
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib34
  article-title: Claudin-based barrier in simple and stratified cellular sheets
  publication-title: Curr Opin Cell Biol
  doi: 10.1016/S0955-0674(02)00362-9
  contributor:
    fullname: Tsukita
– volume: 156
  start-page: 1099
  year: 2002
  ident: 10.1016/j.jid.2019.06.150_bib46
  article-title: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
  publication-title: J Cell Biol
  doi: 10.1083/jcb.200110122
  contributor:
    fullname: Furuse
– volume: 135
  start-page: 39
  year: 2015
  ident: 10.1016/j.jid.2019.06.150_bib18
  article-title: Longitudinal, 3D in vivo imaging of sebaceous glands by coherent anti-stokes Raman scattering microscopy: normal function and response to cryotherapy
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2014.293
  contributor:
    fullname: Jung
– volume: 196
  start-page: 21
  year: 1998
  ident: 10.1016/j.jid.2019.06.150_bib45
  article-title: The human sebocyte culture model provides new insights into development and management of seborrhoea and acne
  publication-title: Dermatology
  doi: 10.1159/000017861
  contributor:
    fullname: Zouboulis
– volume: 115
  start-page: 1449
  year: 1991
  ident: 10.1016/j.jid.2019.06.150_bib49
  article-title: A 220-kD undercoat-constitutive protein: its specific localization at cadherin-based cell-cell adhesion sites
  publication-title: J Cell Biol
  doi: 10.1083/jcb.115.5.1449
  contributor:
    fullname: Itoh
– volume: 5
  year: 2016
  ident: 10.1016/j.jid.2019.06.150_bib38
  article-title: Epidermal cell turnover across tight junctions based on Kelvin's tetrakaidecahedron cell shape
  publication-title: ELife
  doi: 10.7554/eLife.19593
  contributor:
    fullname: Yokouchi
– volume: 49
  start-page: 27
  year: 2016
  ident: 10.1016/j.jid.2019.06.150_bib3
  article-title: Importance of tight junctions in relation to skin barrier function
  publication-title: Curr Probl Dermatol
  doi: 10.1159/000441541
  contributor:
    fullname: Brandner
– volume: 113
  start-page: 1011
  year: 1999
  ident: 10.1016/j.jid.2019.06.150_bib53
  article-title: Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95)
  publication-title: J Invest Dermatol
  doi: 10.1046/j.1523-1747.1999.00771.x
  contributor:
    fullname: Zouboulis
– volume: 206
  start-page: 2937
  year: 2009
  ident: 10.1016/j.jid.2019.06.150_bib21
  article-title: External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
  publication-title: J Exp Med
  doi: 10.1084/jem.20091527
  contributor:
    fullname: Kubo
– volume: 69
  start-page: 148
  year: 2013
  ident: 10.1016/j.jid.2019.06.150_bib41
  article-title: Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2012.11.595
  contributor:
    fullname: Yuki
– volume: 77
  start-page: 28
  year: 2015
  ident: 10.1016/j.jid.2019.06.150_bib52
  article-title: Epidermal tight junction barrier function is altered by skin inflammation, but not by filaggrin-deficient stratum corneum
  publication-title: J Dermatol Sci
  doi: 10.1016/j.jdermsci.2014.11.007
  contributor:
    fullname: Yokouchi
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Title Holocrine Secretion Occurs outside the Tight Junction Barrier in Multicellular Glands: Lessons from Claudin-1–Deficient Mice
URI https://dx.doi.org/10.1016/j.jid.2019.06.150
https://www.ncbi.nlm.nih.gov/pubmed/31445004
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