Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms

Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composi...

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Published inFrontiers in endocrinology (Lausanne) Vol. 11; p. 125
Main Authors Zhou, He, Sun, Lin, Zhang, Siwen, Zhao, Xue, Gang, Xiaokun, Wang, Guixia
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 24.03.2020
Subjects
Animals
causality
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - pathology
dysbiosis
Dysbiosis - complications
Endocrinology
Gastrointestinal Microbiome - immunology
gut microbiota
Humans
Immune System - immunology
Immune System - microbiology
mechanisms
type 1 diabetes
type 1 diabetes
mechanisms
gut microbiota
causality
dysbiosis
Online AccessGet full text
ISSN1664-2392
1664-2392
DOI10.3389/fendo.2020.00125

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Abstract Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.
AbstractList Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.
Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of high-throughput sequencing has allowed us to investigate the role of gut microbiota in the development of T1D. Significant changes in the composition of gut microbiome, also termed dysbiosis, have been found in subjects with clinical or preclinical T1D. However, whether the dysbiosis is a cause or an effect of the disease remains unclear. Currently, increasing evidence has supported a causal link between intestine microflora and T1D development. The current review will focus on recent research regarding the associations between intestine microbiome and T1D progression with an intention to evaluate the causality. We will also discuss the possible mechanisms by which imbalanced gut microbiota leads to the development of T1D.
Author Gang, Xiaokun
Sun, Lin
Zhao, Xue
Zhang, Siwen
Zhou, He
Wang, Guixia
AuthorAffiliation Department of Endocrinology and Metabolism, The First Hospital of Jilin University , Changchun , China
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Keywords type 1 diabetes
mechanisms
gut microbiota
causality
dysbiosis
Language English
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This article was submitted to Clinical Diabetes, a section of the journal Frontiers in Endocrinology
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Snippet Type 1 diabetes (T1D) is a multifactorial autoimmune disease mediated by genetic, epigenetic, and environmental factors. In recent years, the emergence of...
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StartPage 125
SubjectTerms Animals
causality
Diabetes Mellitus, Type 1 - etiology
Diabetes Mellitus, Type 1 - pathology
dysbiosis
Dysbiosis - complications
Endocrinology
Gastrointestinal Microbiome - immunology
gut microbiota
Humans
Immune System - immunology
Immune System - microbiology
mechanisms
type 1 diabetes
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Title Evaluating the Causal Role of Gut Microbiota in Type 1 Diabetes and Its Possible Pathogenic Mechanisms
URI https://www.ncbi.nlm.nih.gov/pubmed/32265832
https://www.proquest.com/docview/2387690283
https://pubmed.ncbi.nlm.nih.gov/PMC7105744
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Volume 11
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