Probing Functional Changes in Exocyst Configuration with Monoclonal Antibodies

• Published in: Frontiers in cell and developmental biology Vol. 4; p. 51
• Main Authors: Inamdar, Shivangi M, Hsu, Shu-Chan, Yeaman, Charles
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 03.06.2016
• Subjects: Cell and Developmental Biology; Cell Polarity; Epithelium; exocyst; Mammals; Membrane trafficking; Monoclonal antibody; epithelium; cell polarity; mammals; monoclonal antibody; exocyst; membrane trafficking

Spatial regulation of exocytosis relies on the exocyst, a hetero-octameric protein complex that tethers vesicles to fusion sites at the plasma membrane. Nevertheless, our understanding of mechanisms regulating exocyst assembly/disassembly, localization, and function are incomplete. Here, we have exp...