Characterization and use of HapT1-derived homologous tumors as a preclinical model to evaluate therapeutic efficacy of drugs against pancreatic tumor desmoplasia

• Published in: Oncotarget Vol. 7; no. 27; pp. 41825 - 41842
• Main Authors: Suklabaidya, Sujit, Das, Biswajit, Ali, Syed Azmal, Jain, Sumeet, Swaminathan, Sharada, Mohanty, Ashok K., Panda, Susen K., Dash, Pujarini, Chakraborty, Subhankar, Batra, Surinder K., Senapati, Shantibhusan
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 05.07.2016
• Subjects: Acetylcysteine - administration & dosage; Animals; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Cell Line, Tumor; Disulfiram - administration & dosage; Fibrosis - prevention & control; Guinea Pigs; Humans; Pancreas - drug effects; Pancreas - pathology; Pancreatic Neoplasms - drug therapy; Pancreatic Stellate Cells - drug effects; Pyridones - administration & dosage; Rats; Research Paper; Xenograft Model Antitumor Assays - methods; HapT1; pancreatic stellate cells; pancreatic cancer; hamster homologous orthotopic model; desmoplasia

Desmoplasia in human pancreatic cancer (PC) promotes cancer progression and hinders effective drug delivery. The objectives of this study were to characterize a homologous orthotopic model of PC in Syrian golden hamster and investigate the effect of anti-fibrotic (pirfenidone), antioxidant (N-acetyl...