Circular RNAs: Biogenesis, Function and Role in Human Diseases

• Published in: Frontiers in molecular biosciences Vol. 4; p. 38
• Main Authors: Greene, John, Baird, Anne-Marie, Brady, Lauren, Lim, Marvin, Gray, Steven G., McDermott, Raymond, Finn, Stephen P.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.06.2017
• Subjects: cancer; circRNAs; diseases; miRNA; Molecular Biosciences; non-coding RNA; circRNAs; diseases; miRNA; cancer; non-coding RNA

Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike linear RNAs, form covalently closed continuous loops and act as gene regulators in mammals. They were originally thought to represent errors in splicing and considered to be of low abundance, however, there is now...