Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats

• Published in: Hypertension research Vol. 41; no. 10; pp. 798 - 808
• Main Authors: Rodriguez, Ruben, Moreno, Meagan, Lee, Andrew Y, Godoy-Lugo, Jose A, Nakano, Daisuke, Nishiyama, Akira, Parkes, David, Awayda, Mouhamed S, Ortiz, Rudy M
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.10.2018
• Subjects: GLP-1 receptor agonists; Obesity; Rodents; Sodium

Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT ) signaling on obesity-associated impairme...