Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats
Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT ) signaling on obesity-associated impairme...
Saved in:
Published in | Hypertension research Vol. 41; no. 10; pp. 798 - 808 |
---|---|
Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Nature Publishing Group
01.10.2018
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na
reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT
) signaling on obesity-associated impairment of urinary Na
excretion (U
V) and elevated arterial pressure, we measured mean arterial pressure (MAP) and heart rate by radiotelemetry and metabolic parameters for 40 days. We tested the hypothesis that stimulation of GLP-1 signaling provides added benefit to blockade of AT
by increasing U
V and further reducing arterial pressure in the following groups: (1) untreated Long-Evans Tokushima Otsuka (LETO) rats (n = 7); (2) untreated Otsuka Long-Evans Tokushima Fatty (OLETF) rats (n = 9); (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day; n = 9); (4) OLETF + GLP-1 receptor agonist (EXE; 10 µg exenatide/kg/day; n = 7); and (5) OLETF + ARB + EXE (Combo; n = 6). On day 2, U
V was 60% and 62% reduced in the EXE and Combo groups, respectively, compared with that in the OLETF rats. On day 40, U
V was increased 69% in the Combo group compared with that in the OLETF group. On day 40, urinary angiotensinogen was 4.5-fold greater in the OLETF than in the LETO group and was 56%, 62%, and 58% lower in the ARB, EXE, and Combo groups, respectively, than in the OLETF group. From day 2 to the end of the study, MAP was lower in the ARB and Combo groups than in the OLETF rats. These results suggest that GLP-1 receptor activation may reduce intrarenal angiotensin II activity, and that simultaneous blockade of AT
increases U
V in obesity; however, these beneficial effects do not translate to a further reduction in MAP. |
---|---|
AbstractList | Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na
reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT
) signaling on obesity-associated impairment of urinary Na
excretion (U
V) and elevated arterial pressure, we measured mean arterial pressure (MAP) and heart rate by radiotelemetry and metabolic parameters for 40 days. We tested the hypothesis that stimulation of GLP-1 signaling provides added benefit to blockade of AT
by increasing U
V and further reducing arterial pressure in the following groups: (1) untreated Long-Evans Tokushima Otsuka (LETO) rats (n = 7); (2) untreated Otsuka Long-Evans Tokushima Fatty (OLETF) rats (n = 9); (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day; n = 9); (4) OLETF + GLP-1 receptor agonist (EXE; 10 µg exenatide/kg/day; n = 7); and (5) OLETF + ARB + EXE (Combo; n = 6). On day 2, U
V was 60% and 62% reduced in the EXE and Combo groups, respectively, compared with that in the OLETF rats. On day 40, U
V was increased 69% in the Combo group compared with that in the OLETF group. On day 40, urinary angiotensinogen was 4.5-fold greater in the OLETF than in the LETO group and was 56%, 62%, and 58% lower in the ARB, EXE, and Combo groups, respectively, than in the OLETF group. From day 2 to the end of the study, MAP was lower in the ARB and Combo groups than in the OLETF rats. These results suggest that GLP-1 receptor activation may reduce intrarenal angiotensin II activity, and that simultaneous blockade of AT
increases U
V in obesity; however, these beneficial effects do not translate to a further reduction in MAP. Obesity is associated with an inappropriately activated renin–angiotensin–aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na+ reabsorption, and hypertension. To assess the link between GLP-1 and angiotensin receptor type 1 (AT1) signaling on obesity-associated impairment of urinary Na+ excretion (UNaV) and elevated arterial pressure, we measured mean arterial pressure (MAP) and heart rate by radiotelemetry and metabolic parameters for 40 days. We tested the hypothesis that stimulation of GLP-1 signaling provides added benefit to blockade of AT1 by increasing UNaV and further reducing arterial pressure in the following groups: (1) untreated Long–Evans Tokushima Otsuka (LETO) rats (n = 7); (2) untreated Otsuka Long–Evans Tokushima Fatty (OLETF) rats (n = 9); (3) OLETF + ARB (ARB; 10 mg olmesartan/kg/day; n = 9); (4) OLETF + GLP-1 receptor agonist (EXE; 10 µg exenatide/kg/day; n = 7); and (5) OLETF + ARB + EXE (Combo; n = 6). On day 2, UNaV was 60% and 62% reduced in the EXE and Combo groups, respectively, compared with that in the OLETF rats. On day 40, UNaV was increased 69% in the Combo group compared with that in the OLETF group. On day 40, urinary angiotensinogen was 4.5-fold greater in the OLETF than in the LETO group and was 56%, 62%, and 58% lower in the ARB, EXE, and Combo groups, respectively, than in the OLETF group. From day 2 to the end of the study, MAP was lower in the ARB and Combo groups than in the OLETF rats. These results suggest that GLP-1 receptor activation may reduce intrarenal angiotensin II activity, and that simultaneous blockade of AT1 increases UNaV in obesity; however, these beneficial effects do not translate to a further reduction in MAP. |
Author | Godoy-Lugo, Jose A Nakano, Daisuke Parkes, David Moreno, Meagan Nishiyama, Akira Ortiz, Rudy M Rodriguez, Ruben Lee, Andrew Y Awayda, Mouhamed S |
Author_xml | – sequence: 1 givenname: Ruben surname: Rodriguez fullname: Rodriguez, Ruben email: rrodriguez3@ucmerced.edu organization: Department of Molecular and Cellular Biology, University of California Merced, Merced, CA, USA. rrodriguez3@ucmerced.edu – sequence: 2 givenname: Meagan surname: Moreno fullname: Moreno, Meagan organization: Department of Molecular and Cellular Biology, University of California Merced, Merced, CA, USA – sequence: 3 givenname: Andrew Y surname: Lee fullname: Lee, Andrew Y organization: Department of Molecular and Cellular Biology, University of California Merced, Merced, CA, USA – sequence: 4 givenname: Jose A surname: Godoy-Lugo fullname: Godoy-Lugo, Jose A organization: Department of Molecular and Cellular Biology, University of California Merced, Merced, CA, USA – sequence: 5 givenname: Daisuke surname: Nakano fullname: Nakano, Daisuke organization: Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan – sequence: 6 givenname: Akira surname: Nishiyama fullname: Nishiyama, Akira organization: Department of Pharmacology, Kagawa University Medical School, Kagawa, Japan – sequence: 7 givenname: David surname: Parkes fullname: Parkes, David organization: DGP Scientific, Inc., Del Mar, CA, USA – sequence: 8 givenname: Mouhamed S surname: Awayda fullname: Awayda, Mouhamed S organization: Department of Physiology and Biophysics, University of Buffalo, Buffalo, NY, USA – sequence: 9 givenname: Rudy M surname: Ortiz fullname: Ortiz, Rudy M organization: Department of Molecular and Cellular Biology, University of California Merced, Merced, CA, USA |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29985448$$D View this record in MEDLINE/PubMed |
BookMark | eNpdkdFqFTEQhoNU7Gn1AbyRgDfebM1ks9nkUkpbhQMVrNchm51I6p5kTbKCr-LTmnKqQi9mJgzf_xPmPyMnMUUk5DWwC2C9el8ECME6BqpjbGyPZ2QHvVCd4CBOyI5pkJ2WvTwlZ6XcM8bVoOEFOeVaq0EItSO_v4TDtlQbMW2F3uw_d0AzOlxrytS6Gn7aGlKkNs6tvoVUMZYQ_zPTktx3OyMN0WW0BWm0NYctYwmlLWdcsbVYafLULhUzNqfcZrALXRtWGttAmiZs6tv91d01zbaWl-S5t0vBV4_znHy9vrq7_Njtb28-XX7Yd05IXrtZc24lc1OPYpgVZ2IcNdPKzc4zzTX3gGocnB8mD2NrGpxmk5e6V96LoT8n746-a04_NizVHEJxuCzHoxjO5Ai9Vko29O0T9D5tObbfGQ4gRasBGgVHyuVUSkZv1hwONv8ywMxDcOYYnGnBmYfgDGuaN4_O23TA-Z_ib1L9H53gl6Y |
CitedBy_id | crossref_primary_10_1186_s12933_020_01029_0 crossref_primary_10_1111_1440_1681_13206 crossref_primary_10_1038_s41440_018_0085_6 crossref_primary_10_1111_1440_1681_13738 crossref_primary_10_3389_fendo_2020_00363 crossref_primary_10_1152_ajpendo_00374_2023 |
Cites_doi | 10.1152/physiolgenomics.00056.2015 10.1152/ajprenal.00082.2009 10.1186/s12933-014-0162-3 10.1161/CIRCRESAHA.116.305697 10.1161/01.HYP.33.6.1470 10.1161/01.HYP.0000154361.47683.d3 10.1016/0091-7435(87)90087-9 10.1038/hr.2016.2 10.1016/S0167-0115(96)00113-9 10.1016/j.bbrc.2009.01.003 10.1111/dme.12594 10.1152/ajprenal.00124.2007 10.1074/jbc.M110.159194 10.1007/s00125-016-3938-z 10.2337/db13-1440 10.1056/NEJM200003303421301 10.1001/jama.2016.6458 10.1210/en.2011-1885 10.1097/HJH.0b013e3283060efa 10.1038/ajh.2011.8 10.1016/j.mce.2008.08.012 10.1016/S0303-7207(98)00096-3 10.1098/rstb.2006.1857 10.1152/ajprenal.00504.2006 10.1210/jc.2012-3855 10.2337/db09-0281 10.1016/j.amjhyper.2004.08.025 10.1038/nature05488 10.1038/nature05482 10.1056/NEJMoa065061 10.1007/s12020-014-0519-0 10.1097/FJC.0000000000000258 10.1038/hr.2014.173 10.1152/ajprenal.00729.2010 10.1161/01.HYP.36.4.594 10.2337/db14-1751 10.1056/NEJMcp0909392 10.1152/ajprenal.00394.2015 10.1124/pr.59.3.3 10.1016/j.amjhyper.2004.05.017 10.1152/ajpendo.90207.2008 10.1161/HYPERTENSIONAHA.108.119404 10.2337/db14-0976 10.1152/ajprenal.00259.2012 10.1172/JCI0215595 10.1152/ajprenal.00240.2006 10.1111/dom.12651 10.1161/01.HYP.0000052314.95497.78 10.1038/nm.3128 10.1111/j.1463-1326.2012.01663.x 10.1007/s11906-015-0621-6 10.1111/dom.12601 |
ContentType | Journal Article |
Copyright | Copyright Nature Publishing Group Oct 2018 |
Copyright_xml | – notice: Copyright Nature Publishing Group Oct 2018 |
DBID | NPM AAYXX CITATION 3V. 7X7 7XB 88E 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH K9. M0S M1P PQEST PQQKQ PQUKI PRINS 7X8 |
DOI | 10.1038/s41440-018-0070-0 |
DatabaseName | PubMed CrossRef ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central AUTh Library subscriptions: ProQuest Central ProQuest One Community College Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni Edition) PML(ProQuest Medical Library) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
DatabaseTitle | PubMed CrossRef ProQuest One Academic Eastern Edition ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Central China ProQuest Hospital Collection (Alumni) ProQuest Central ProQuest Health & Medical Complete Health Research Premium Collection ProQuest Medical Library ProQuest One Academic UKI Edition Health and Medicine Complete (Alumni Edition) ProQuest One Academic ProQuest Medical Library (Alumni) ProQuest Central (Alumni) MEDLINE - Academic |
DatabaseTitleList | PubMed ProQuest One Academic Eastern Edition |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X7 name: Health & Medical Collection url: https://search.proquest.com/healthcomplete sourceTypes: Aggregation Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1348-4214 |
EndPage | 808 |
ExternalDocumentID | 10_1038_s41440_018_0070_0 29985448 |
Genre | Journal Article |
GroupedDBID | --- -Q- .55 0R~ 29I 2WC 39C 3V. 4.4 406 53G 5GY 70F 7X7 88E 8FI 8FJ AACDK AANZL AASML AATNV AAWBL AAZLF ABAKF ABAWZ ABJNI ABLJU ABUWG ABZZP ACAOD ACGFO ACGFS ACKTT ACMJI ACRQY ACZOJ ADBBV ADHDB AEFQL AEJRE AEMSY AENEX AESKC AEVLU AEXYK AFBBN AFKRA AFSHS AGAYW AGEZK AGHAI AGQEE AHMBA AHSBF AIGIU AILAN AJRNO ALFFA ALIPV ALMA_UNASSIGNED_HOLDINGS AMYLF AXYYD BAWUL BENPR BKKNO BPHCQ BVXVI CCPQU CS3 DIK DNIVK DPUIP DU5 E3Z EBLON EBS EE. EIOEI EJD EMB EMOBN F5P FDQFY FERAY FIGPU FIZPM FSGXE FYUFA GX1 HMCUK HZ~ IWAJR JSF JSH JSO JZLTJ KQ8 LGEZI LOTEE M1P NADUK NAO NPM NQJWS NXXTH O9- OK1 P2P PQQKQ PROAC PSQYO RJT RNT RNTTT RZJ SNX SNYQT SOHCF SRMVM SV3 SWTZT TAOOD TBHMF TDRGL TKC TR2 TSG UKHRP W2D X7M XSB AAYXX CITATION 7XB 8FK K9. PQEST PQUKI PRINS 7X8 |
ID | FETCH-LOGICAL-c462t-d922a60cb3e45d8204779098cdcf09292f1e875cf5bf175bf91c90bf6938ff453 |
IEDL.DBID | 7X7 |
ISSN | 0916-9636 |
IngestDate | Sat Aug 17 01:04:11 EDT 2024 Tue Dec 17 04:38:42 EST 2024 Fri Aug 23 02:47:42 EDT 2024 Wed Oct 16 00:49:49 EDT 2024 |
IsDoiOpenAccess | false |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c462t-d922a60cb3e45d8204779098cdcf09292f1e875cf5bf175bf91c90bf6938ff453 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
OpenAccessLink | https://escholarship.org/content/qt1x23r646/qt1x23r646.pdf?t=pc08zy |
PMID | 29985448 |
PQID | 2116411651 |
PQPubID | 2043497 |
PageCount | 11 |
ParticipantIDs | proquest_miscellaneous_2067139886 proquest_journals_2116411651 crossref_primary_10_1038_s41440_018_0070_0 pubmed_primary_29985448 |
PublicationCentury | 2000 |
PublicationDate | 2018-10-01 |
PublicationDateYYYYMMDD | 2018-10-01 |
PublicationDate_xml | – month: 10 year: 2018 text: 2018-10-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England – name: Tokyo |
PublicationTitle | Hypertension research |
PublicationTitleAlternate | Hypertens Res |
PublicationYear | 2018 |
Publisher | Nature Publishing Group |
Publisher_xml | – sequence: 0 name: Nature Publishing Group |
References | 30111855 - Hypertens Res. 2018 Oct;41(10):784-786 SE Kahn (70_CR2) 2006; 444 M Zavattaro (70_CR28) 2015; 50 P Richards (70_CR19) 2014; 63 T Rieg (70_CR21) 2012; 303 DG Fuster (70_CR46) 2007; 292 RM Ortiz (70_CR32) 2007; 293 M Lamarre-Cliche (70_CR51) 2005; 18 J Holst (70_CR40) 2009; 297 JE Hall (70_CR7) 1993; 22 A Sufiun (70_CR20) 2015; 38 M Moroi (70_CR25) 2015; 66 H Kobori (70_CR49) 2007; 59 TW Gress (70_CR12) 2000; 342 Y Takeshige (70_CR43) 2016; 39 J Koska (70_CR55) 2015; 64 TH Moran (70_CR30) 2006; 361 H Yamamoto (70_CR54) 2002; 110 K Fujiwara (70_CR6) 1999; 33 J Bosch (70_CR16) 2006; 355 S Engeli (70_CR50) 2005; 45 RM Ortiz (70_CR36) 1999; 70 A Nishiyama (70_CR45) 2008; 26 XC Li (70_CR47) 2015; 47 JM Barragán (70_CR53) 1996; 67 BJ Scholten (70_CR29) 2015; 32 A Goud (70_CR41) 2016; 18 X Zhou (70_CR26) 2015; 14 LX Farah (70_CR48) 2015; 310 JE Hall (70_CR9) 2015; 116 L Tonneijck (70_CR23) 2016; 59 MS Awayda (70_CR33) 2011; 286 J Cacho (70_CR34) 2008; 295 P Bramlage (70_CR10) 2004; 17 J Skov (70_CR39) 2013; 98 K Hirata (70_CR52) 2009; 380 K Færch (70_CR5) 2015; 64 JL Dunphy (70_CR18) 1998; 141 DM Lloyd-Jones (70_CR11) 2000; 36 JW Eriksson (70_CR13) 2008; 52 RM Ortiz (70_CR31) 2007; 293 JE Hall (70_CR8) 2003; 41 J Skov (70_CR24) 2016; 18 RM Ortiz (70_CR35) 1999; 70 RJ Garrison (70_CR4) 1987; 16 G Tocci (70_CR14) 2011; 24 JJ McMurray (70_CR15) 2010; 362 JG Barrera (70_CR42) 2009; 58 LR Carraro-Lacroix (70_CR38) 2009; 297 M Kim (70_CR27) 2013; 19 KM Flegal (70_CR1) 2016; 315 JP Després (70_CR3) 2006; 444 AR Meloni (70_CR17) 2013; 15 RO Crajoinas (70_CR37) 2011; 301 R Rodriguez (70_CR44) 2012; 153 MHA Muskiet (70_CR22) 2016; 18 |
References_xml | – volume: 47 start-page: 479 year: 2015 ident: 70_CR47 publication-title: Physiol Genom doi: 10.1152/physiolgenomics.00056.2015 contributor: fullname: XC Li – volume: 297 start-page: F1647 year: 2009 ident: 70_CR38 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00082.2009 contributor: fullname: LR Carraro-Lacroix – volume: 14 start-page: 1 year: 2015 ident: 70_CR26 publication-title: Cardiovasc Diabetol doi: 10.1186/s12933-014-0162-3 contributor: fullname: X Zhou – volume: 116 start-page: 991 year: 2015 ident: 70_CR9 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.116.305697 contributor: fullname: JE Hall – volume: 33 start-page: 1470 year: 1999 ident: 70_CR6 publication-title: Hypertension doi: 10.1161/01.HYP.33.6.1470 contributor: fullname: K Fujiwara – volume: 45 start-page: 356 year: 2005 ident: 70_CR50 publication-title: Hypertension doi: 10.1161/01.HYP.0000154361.47683.d3 contributor: fullname: S Engeli – volume: 16 start-page: 235 year: 1987 ident: 70_CR4 publication-title: Prev Med doi: 10.1016/0091-7435(87)90087-9 contributor: fullname: RJ Garrison – volume: 39 start-page: 415 year: 2016 ident: 70_CR43 publication-title: Hypertens Res doi: 10.1038/hr.2016.2 contributor: fullname: Y Takeshige – volume: 67 start-page: 63 year: 1996 ident: 70_CR53 publication-title: Regul Pept doi: 10.1016/S0167-0115(96)00113-9 contributor: fullname: JM Barragán – volume: 380 start-page: 44 year: 2009 ident: 70_CR52 publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2009.01.003 contributor: fullname: K Hirata – volume: 70 start-page: 1089 year: 1999 ident: 70_CR35 publication-title: Aviat Space Environ Med contributor: fullname: RM Ortiz – volume: 32 start-page: 343 year: 2015 ident: 70_CR29 publication-title: Diabet Med doi: 10.1111/dme.12594 contributor: fullname: BJ Scholten – volume: 293 start-page: F1584 year: 2007 ident: 70_CR31 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00124.2007 contributor: fullname: RM Ortiz – volume: 286 start-page: 1683 year: 2011 ident: 70_CR33 publication-title: J Biol Chem doi: 10.1074/jbc.M110.159194 contributor: fullname: MS Awayda – volume: 59 start-page: 1412 year: 2016 ident: 70_CR23 publication-title: Diabetologia doi: 10.1007/s00125-016-3938-z contributor: fullname: L Tonneijck – volume: 63 start-page: 1224 year: 2014 ident: 70_CR19 publication-title: Diabetes doi: 10.2337/db13-1440 contributor: fullname: P Richards – volume: 342 start-page: 905 year: 2000 ident: 70_CR12 publication-title: N Engl J Med doi: 10.1056/NEJM200003303421301 contributor: fullname: TW Gress – volume: 315 start-page: 2284 year: 2016 ident: 70_CR1 publication-title: JAMA doi: 10.1001/jama.2016.6458 contributor: fullname: KM Flegal – volume: 153 start-page: 1684 year: 2012 ident: 70_CR44 publication-title: Endocrinology doi: 10.1210/en.2011-1885 contributor: fullname: R Rodriguez – volume: 26 start-page: 1849 year: 2008 ident: 70_CR45 publication-title: J Hypertens doi: 10.1097/HJH.0b013e3283060efa contributor: fullname: A Nishiyama – volume: 24 start-page: 582 year: 2011 ident: 70_CR14 publication-title: Am J Hypertens doi: 10.1038/ajh.2011.8 contributor: fullname: G Tocci – volume: 297 start-page: 127 year: 2009 ident: 70_CR40 publication-title: Mol Cell Endocrinol doi: 10.1016/j.mce.2008.08.012 contributor: fullname: J Holst – volume: 141 start-page: 179 year: 1998 ident: 70_CR18 publication-title: Mol Cell Endocrinol doi: 10.1016/S0303-7207(98)00096-3 contributor: fullname: JL Dunphy – volume: 361 start-page: 1211 year: 2006 ident: 70_CR30 publication-title: Philos Trans R Soc Lond B Biol Sci doi: 10.1098/rstb.2006.1857 contributor: fullname: TH Moran – volume: 293 start-page: F139 year: 2007 ident: 70_CR32 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00504.2006 contributor: fullname: RM Ortiz – volume: 98 start-page: E664 year: 2013 ident: 70_CR39 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2012-3855 contributor: fullname: J Skov – volume: 58 start-page: 2820 year: 2009 ident: 70_CR42 publication-title: Diabetes doi: 10.2337/db09-0281 contributor: fullname: JG Barrera – volume: 18 start-page: 56 year: 2005 ident: 70_CR51 publication-title: Am J Hypertens doi: 10.1016/j.amjhyper.2004.08.025 contributor: fullname: M Lamarre-Cliche – volume: 444 start-page: 881 year: 2006 ident: 70_CR3 publication-title: Nature doi: 10.1038/nature05488 contributor: fullname: JP Després – volume: 444 start-page: 840 year: 2006 ident: 70_CR2 publication-title: Nature doi: 10.1038/nature05482 contributor: fullname: SE Kahn – volume: 70 start-page: 499 year: 1999 ident: 70_CR36 publication-title: Aviat Space Environ Med contributor: fullname: RM Ortiz – volume: 355 start-page: 1551 year: 2006 ident: 70_CR16 publication-title: N Engl J Med doi: 10.1056/NEJMoa065061 contributor: fullname: J Bosch – volume: 50 start-page: 620 year: 2015 ident: 70_CR28 publication-title: Endocrine doi: 10.1007/s12020-014-0519-0 contributor: fullname: M Zavattaro – volume: 22 start-page: 292 year: 1993 ident: 70_CR7 publication-title: Ren Funct Syst hemodynamics Hypertens contributor: fullname: JE Hall – volume: 66 start-page: 159 year: 2015 ident: 70_CR25 publication-title: J Cardiovasc Pharmacol doi: 10.1097/FJC.0000000000000258 contributor: fullname: M Moroi – volume: 38 start-page: 237 year: 2015 ident: 70_CR20 publication-title: Hypertens Res doi: 10.1038/hr.2014.173 contributor: fullname: A Sufiun – volume: 301 start-page: F355 year: 2011 ident: 70_CR37 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00729.2010 contributor: fullname: RO Crajoinas – volume: 36 start-page: 594 year: 2000 ident: 70_CR11 publication-title: Hypertension doi: 10.1161/01.HYP.36.4.594 contributor: fullname: DM Lloyd-Jones – volume: 64 start-page: 2513 year: 2015 ident: 70_CR5 publication-title: Diabetes doi: 10.2337/db14-1751 contributor: fullname: K Færch – volume: 362 start-page: 1477 year: 2010 ident: 70_CR15 publication-title: N Engl J Med doi: 10.1056/NEJMcp0909392 contributor: fullname: JJ McMurray – volume: 310 start-page: F123 year: 2015 ident: 70_CR48 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00394.2015 contributor: fullname: LX Farah – volume: 59 start-page: 251 year: 2007 ident: 70_CR49 publication-title: Pharmacol Rev doi: 10.1124/pr.59.3.3 contributor: fullname: H Kobori – volume: 17 start-page: 904 year: 2004 ident: 70_CR10 publication-title: Am J Hypertens doi: 10.1016/j.amjhyper.2004.05.017 contributor: fullname: P Bramlage – volume: 295 start-page: E1269 year: 2008 ident: 70_CR34 publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.90207.2008 contributor: fullname: J Cacho – volume: 52 start-page: 1030 year: 2008 ident: 70_CR13 publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.108.119404 contributor: fullname: JW Eriksson – volume: 64 start-page: 2624 year: 2015 ident: 70_CR55 publication-title: Diabetes doi: 10.2337/db14-0976 contributor: fullname: J Koska – volume: 303 start-page: F963 year: 2012 ident: 70_CR21 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00259.2012 contributor: fullname: T Rieg – volume: 110 start-page: 43 year: 2002 ident: 70_CR54 publication-title: J Clin Invest doi: 10.1172/JCI0215595 contributor: fullname: H Yamamoto – volume: 292 start-page: F577 year: 2007 ident: 70_CR46 publication-title: Am J Physiol Ren Physiol doi: 10.1152/ajprenal.00240.2006 contributor: fullname: DG Fuster – volume: 18 start-page: 581 year: 2016 ident: 70_CR24 publication-title: Diabetes Obes Metab doi: 10.1111/dom.12651 contributor: fullname: J Skov – volume: 41 start-page: 625 year: 2003 ident: 70_CR8 publication-title: Hypertension doi: 10.1161/01.HYP.0000052314.95497.78 contributor: fullname: JE Hall – volume: 19 start-page: 567 year: 2013 ident: 70_CR27 publication-title: Nat Med doi: 10.1038/nm.3128 contributor: fullname: M Kim – volume: 15 start-page: 15 year: 2013 ident: 70_CR17 publication-title: Diabetes, Obes Metab doi: 10.1111/j.1463-1326.2012.01663.x contributor: fullname: AR Meloni – volume: 18 start-page: 16 year: 2016 ident: 70_CR41 publication-title: Curr Hypertens Rep doi: 10.1007/s11906-015-0621-6 contributor: fullname: A Goud – volume: 18 start-page: 178 year: 2016 ident: 70_CR22 publication-title: Diabetes, Obes Metab doi: 10.1111/dom.12601 contributor: fullname: MHA Muskiet |
SSID | ssj0028591 |
Score | 2.291129 |
Snippet | Obesity is associated with an inappropriately activated renin-angiotensin-aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na... Obesity is associated with an inappropriately activated renin–angiotensin–aldosterone system, suppressed glucagon-like peptide-1 (GLP-1), increased renal Na+... |
SourceID | proquest crossref pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 798 |
SubjectTerms | GLP-1 receptor agonists Obesity Rodents Sodium |
Title | Simultaneous GLP-1 receptor activation and angiotensin receptor blockade increase natriuresis independent of altered arterial pressure in obese OLETF rats |
URI | https://www.ncbi.nlm.nih.gov/pubmed/29985448 https://www.proquest.com/docview/2116411651 https://search.proquest.com/docview/2067139886 |
Volume | 41 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1NT9wwELVakKpeKugXSwG5Uk-VLJLYMc6pYtEuCMEWtSDtzfLHuIoqJUuz_Bl-LWMnu6se4BDlECeRPM-eN57xMyHfhDTOCguMgwKG_L_CMVdKZmzwYNBlVDzuRr6eyYs7cTkv58OCWzeUVa7mxDRR-9bFNfJjDFSkiFox-Y_FPYunRsXs6nCExmuynRfoyhHPJ_NNwBW12ZLWXi4ZAk2usppcHXciZTWzXLGoeMOy__3SM2QzOZ3pDnk3sEV62pt3l7yC5j15cz3kwz-Qx991rAg0DWAAT8-vblhOcQqDBUbSNG5Z6BdcqWk8Xn_qNtWrN5s2Fn3ZX-OB1k2kjx3QJmr2P2AQXne0Xp-Ru6RtoCmzDvilWAaKuKWpiBbbYkPaWsC3f15NbqcUUdV9JHfTye3ZBRtOW2BOyGLJfFUURmbOchClR2IgohRhpZx3IUMSVYQc0IwulDYg57Chyl2V2SArrkIQJf9Etpq2gT1CTWkKY6xyxjsBnFuOYSNyHec9z6AqRuT7qq_1ohfV0CkZzpXuDaPRMDoaRmcjcrCyhh7GV6c3aBiRr-vHODJiuqPvdB2F6ZHfKiVH5HNvxfXf0AmrEpG5__LHv5C3RYRIKt47IFvLfw9wiCRkaY8S0o7I9ul0PJ7hfTyZ3fx6AujN3yU |
link.rule.ids | 314,780,784,12056,21388,27924,27925,31719,31720,33744,33745,43310,43805,73745,74302 |
linkProvider | ProQuest |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lj9MwEB5BV4K9IN4UFjASJyRrk9ixnBMC1FKgLSvoSnuz_EQRUtIl3T_Dr2UmSbviAIec4jiSZ8bzjWf8DcBrqax30kUuoo4c8X-FNlcqbl0K0aLLqATdRl6t1eJcfr4oL8YDt24sq9zvif1GHVpPZ-SnGKgoSVwx-dvtJaeuUZRdHVto3IQjYk4vJ3D0frY--3YIuYidrWfbyxVHVVP7vKbQp53s85pZrjlx3vDsb8_0D7jZu535Xbgz4kX2bhDwPbgRm_twazVmxB_A7-811QTaJmIIzz4uz3jOcBOLW4ylGV1aGI5cmW0CPj_qtq9Yb67HOPRmP22IrG4IQHaRNcTaf4VheN2x-tAld8faxPrcesSZqBAUNZf1ZbQ4Fgey1kX8-utytpkz1KvuIZzPZ5sPCz72W-BeqmLHQ1UUVmXeiSjLgNBAEhlhpX3wKUMYVaQ8oiB9Kl1C1OFSlfsqc0lVQqckS_EIJk3bxCfAbGkLa532NngZhXACA0dEOz4EkcWqmMKb_Vqb7UCrYfp0uNBmEIxBwRgSjMmmcLKXhhktrDPX-jCFV4fXaBuU8BgW3RA1PSJcrdUUHg9SPPwN3bAuUTef_n_yl3B7sVktzfLT-sszOC5IXfpSvhOY7H5dxecISXbuxah3fwBX_-Bl |
linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVqq4IN7dUsBInJCsTWLHck6Ixy4FtssKWqk3y08UISVLs_0z_FrGjncrDnDIKY4jecaebzyfPwO84kJbw42nzEtPEf83OOdqQbUJzmsMGQ2Lp5HPVuL0gn--rC8z_2nItMrdmpgWatfbuEc-w0RF8KgVU85CpkWsPyzebH7ReINUrLTm6zRuwwFGxaKawMG7-Wr9bZ9-RaW2pLxXCopuJ3Y1TiZnA081zqKUNOrf0OLvKPUP6JlC0OIe3M3YkbwdjX0fbvnuARye5er4Q_j9vY38QN15TOfJx-WalgQXNL_BvJrEAwzj9ivRncPnR9sn9np308ZgZPupnSdtF8Hk4EkXFfyvMSVvB9Lub8zdkj6QVGf32FMkhaIXk0SpxbbYkPTG49dfl_PzBUEfGx7BxWJ-_v6U5rsXqOWi2lLXVJUWhTXM89ohTOBRmLCR1tlQIKSqQunRqDbUJiACMaEpbVOYIBomQ-A1ewyTru_8ERBd60prI612lnvGDMMkEpGPdY4Vvqmm8Ho31mozSmyoVBpnUo2GUWgYFQ2jiimc7Kyh8mwb1I1vTOHl_jXOk1j8GAddRZl6RLtSiik8Ga24_xuGZFmjnx7_v_MXcIgup5afVl-ewp0qekti9Z3AZHt17Z8hOtma59nt_gCsnOSS |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Simultaneous+GLP-1+receptor+activation+and+angiotensin+receptor+blockade+increase+natriuresis+independent+of+altered+arterial+pressure+in+obese+OLETF+rats&rft.jtitle=Hypertension+research&rft.au=Rodriguez%2C+Ruben&rft.au=Moreno%2C+Meagan&rft.au=Lee%2C+Andrew+Y.&rft.au=Godoy-Lugo%2C+Jose+A.&rft.date=2018-10-01&rft.issn=0916-9636&rft.eissn=1348-4214&rft.volume=41&rft.issue=10&rft.spage=798&rft.epage=808&rft_id=info:doi/10.1038%2Fs41440-018-0070-0&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s41440_018_0070_0 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0916-9636&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0916-9636&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0916-9636&client=summon |