Mitochondrial Supercomplexes: Physiological Organization and Dysregulation in Age-Related Neurodegenerative Disorders

• Published in: Frontiers in endocrinology (Lausanne) Vol. 11; p. 600
• Main Authors: Novack, Gisela V, Galeano, Pablo, Castaño, Eduardo M, Morelli, Laura
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 11.09.2020
• Subjects: Aging - metabolism; Aging - pathology; Alzheimer's disease; Animals; Brain - metabolism; Brain - pathology; Electron Transport Complex I - genetics; Electron Transport Complex I - metabolism; Electron Transport Complex IV - genetics; Electron Transport Complex IV - metabolism; Endocrinology; Energy Metabolism - physiology; Humans; Mitochondria - metabolism; Mitochondria - pathology; Mitochondrial Dynamics - physiology; mitochondrial dysfunction; neurodegeneration; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Neurons - metabolism; Neurons - pathology; Parkinson's disease; Reactive Oxygen Species - metabolism; respirasome structure; supercomplexes organization; Parkinson's disease; supercomplexes organization; neurodegeneration; mitochondrial dysfunction; Alzheimer's disease; respirasome structure; brain bioenergetics

Several studies suggest that the assembly of mitochondrial respiratory complexes into structures known as supercomplexes (SCs) may increase the efficiency of the electron transport chain, reducing the rate of production of reactive oxygen species. Therefore, the study of the (dis)assembly of SCs may...