Size- and time-dependent alteration in metabolic activities of human hepatic cytochrome P450 isozymes by gold nanoparticles via microsomal coincubations

• Published in: Nanoscale research letters Vol. 9; no. 1; p. 642
• Main Authors: Ye, Meiling, Tang, Ling, Luo, Mengjun, Zhou, Jing, Guo, Bin, Liu, Yangyuan, Chen, Bo
• Format: Journal Article
• Language: English
• Published: New York Springer New York 28.11.2014; Springer Nature B.V; Springer
• Subjects: Adenine; Chemistry and Materials Science; CYP2D6 protein; Cytochrome; Cytochrome P450; Cytochromes P450; Drug dosages; Enzymes; Gold; Inactivation; Isoenzymes; Light scattering; Liver; Materials Science; Membrane proteins; Membranes; Metabolism; Microsomes; Molecular Medicine; Nano Express; Nanochemistry; Nanoparticles; Nanoscale Science and Technology; Nanotechnology; Nanotechnology and Microengineering; Nicotinamide; Nicotinamide adenine dinucleotide; Photon correlation spectroscopy; Proteins; Spectroscopy; Tannic acid; Time dependence; Ultraviolet spectroscopy; Zeta potential; Inhibition; Incubation; Nanoprecipitation; Microsome; Cytochrome P450; Gold nanoparticle

Nano-sized particles are known to interfere with drug-metabolizing cytochrome P450 (CYP) enzymes, which can be anticipated to be a potential source of unintended adverse reactions, but the mechanisms underlying the inhibition are still not well understood. Herein we report a systematic investigation...