Preliminary Evidence of Sex Differences in Cortical Thickness Following Acute Mild Traumatic Brain Injury
The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the...
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| Published in | Frontiers in neurology Vol. 9; p. 878 |
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| Main Authors | , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Frontiers Media S.A
17.10.2018
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| Abstract | The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the participants underwent comprehensive neurocognitive assessments and MRI to assess cortical thickness. Significant sex differences were determined by using variance analysis of factorial design. Relations between the cortical thickness and clinical assessments were measured with the Spearman Correlation. Results revealed that patients with mTBI had significantly reduced cortical thickness in the left entorhinal cortex while increased cortical thickness in the left precuneus cortex and right lateral occipital cortex, compared with healthy controls. The interaction effect of the group × sex on cortical thickness was significant. Female patients had significant thicker cortical thickness in the left caudal anterior cingulate cortex (ACC) than male patients and had higher scores on Posttraumatic stress disorder Checklist-Civilian Version (PCL-C). Spearman correlational analysis showed a significantly positive correlations between the cortical thickness of the left caudal ACC and PCL-C ratings in female patients. Sex differences in cortical thickness support its potential as a neuroimaging phenotype for investigating the differences in clinical profiles of mild TBI between women and men. |
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| AbstractList | The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the participants underwent comprehensive neurocognitive assessments and MRI to assess cortical thickness. Significant sex differences were determined by using variance analysis of factorial design. Relations between the cortical thickness and clinical assessments were measured with the Spearman Correlation. Results revealed that patients with mTBI had significantly reduced cortical thickness in the left entorhinal cortex while increased cortical thickness in the left precuneus cortex and right lateral occipital cortex, compared with healthy controls. The interaction effect of the group × sex on cortical thickness was significant. Female patients had significant thicker cortical thickness in the left caudal anterior cingulate cortex (ACC) than male patients and had higher scores on Posttraumatic stress disorder Checklist-Civilian Version (PCL-C). Spearman correlational analysis showed a significantly positive correlations between the cortical thickness of the left caudal ACC and PCL-C ratings in female patients. Sex differences in cortical thickness support its potential as a neuroimaging phenotype for investigating the differences in clinical profiles of mild TBI between women and men. The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the participants underwent comprehensive neurocognitive assessments and MRI to assess cortical thickness. Significant sex differences were determined by using variance analysis of factorial design. Relations between the cortical thickness and clinical assessments were measured with the Spearman Correlation. Results revealed that patients with mTBI had significantly reduced cortical thickness in the left entorhinal cortex while increased cortical thickness in the left precuneus cortex and right lateral occipital cortex, compared with healthy controls. The interaction effect of the group × sex on cortical thickness was significant. Female patients had significant thicker cortical thickness in the left caudal anterior cingulate cortex (ACC) than male patients and had higher scores on Posttraumatic stress disorder Checklist-Civilian Version (PCL-C). Spearman correlational analysis showed a significantly positive correlations between the cortical thickness of the left caudal ACC and PCL-C ratings in female patients. Sex differences in cortical thickness support its potential as a neuroimaging phenotype for investigating the differences in clinical profiles of mild TBI between women and men.The main objective of this study was to evaluate sex differences in cortical thickness after acute mild traumatic brain injury (mTBI) and its associations with clinical outcomes. Thirty-two patients with mTBI at acute phase (2.4 ± 1.3 days post-injury) and 30 healthy controls were enrolled. All the participants underwent comprehensive neurocognitive assessments and MRI to assess cortical thickness. Significant sex differences were determined by using variance analysis of factorial design. Relations between the cortical thickness and clinical assessments were measured with the Spearman Correlation. Results revealed that patients with mTBI had significantly reduced cortical thickness in the left entorhinal cortex while increased cortical thickness in the left precuneus cortex and right lateral occipital cortex, compared with healthy controls. The interaction effect of the group × sex on cortical thickness was significant. Female patients had significant thicker cortical thickness in the left caudal anterior cingulate cortex (ACC) than male patients and had higher scores on Posttraumatic stress disorder Checklist-Civilian Version (PCL-C). Spearman correlational analysis showed a significantly positive correlations between the cortical thickness of the left caudal ACC and PCL-C ratings in female patients. Sex differences in cortical thickness support its potential as a neuroimaging phenotype for investigating the differences in clinical profiles of mild TBI between women and men. |
| Author | Gan, Shuoqiu Hu, Liuxun Gu, Chenghui Yan, Zhihan Cao, Jieli Yin, Bo Sun, Chuanzhu Bai, Guanghui Bai, Lijun Huang, Wenming Shao, Meihua Ye, Limei Wang, Shan Zhang, Danbin |
| AuthorAffiliation | 3 Neurosurgery Department of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China 1 Radiology Department of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University , Wenzhou , China 2 The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi' an Jiaotong University , Xi' an , China |
| AuthorAffiliation_xml | – name: 3 Neurosurgery Department of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University , Wenzhou , China – name: 1 Radiology Department of the Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University , Wenzhou , China – name: 2 The Key Laboratory of Biomedical Information Engineering, Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi' an Jiaotong University , Xi' an , China |
| Author_xml | – sequence: 1 givenname: Meihua surname: Shao fullname: Shao, Meihua – sequence: 2 givenname: Jieli surname: Cao fullname: Cao, Jieli – sequence: 3 givenname: Lijun surname: Bai fullname: Bai, Lijun – sequence: 4 givenname: Wenming surname: Huang fullname: Huang, Wenming – sequence: 5 givenname: Shan surname: Wang fullname: Wang, Shan – sequence: 6 givenname: Chuanzhu surname: Sun fullname: Sun, Chuanzhu – sequence: 7 givenname: Shuoqiu surname: Gan fullname: Gan, Shuoqiu – sequence: 8 givenname: Limei surname: Ye fullname: Ye, Limei – sequence: 9 givenname: Bo surname: Yin fullname: Yin, Bo – sequence: 10 givenname: Danbin surname: Zhang fullname: Zhang, Danbin – sequence: 11 givenname: Chenghui surname: Gu fullname: Gu, Chenghui – sequence: 12 givenname: Liuxun surname: Hu fullname: Hu, Liuxun – sequence: 13 givenname: Guanghui surname: Bai fullname: Bai, Guanghui – sequence: 14 givenname: Zhihan surname: Yan fullname: Yan, Zhihan |
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| CitedBy_id | crossref_primary_10_3389_fneur_2021_755152 crossref_primary_10_1007_s11065_020_09474_0 crossref_primary_10_1002_hbm_25761 crossref_primary_10_1016_j_phrs_2024_107274 crossref_primary_10_1002_jnr_24840 crossref_primary_10_1177_03635465211008596 crossref_primary_10_1002_brb3_2714 crossref_primary_10_1016_j_expneurol_2025_115182 crossref_primary_10_1089_neu_2023_0336 crossref_primary_10_1093_gerona_glad079 crossref_primary_10_1097_HTR_0000000000000631 crossref_primary_10_1080_02699052_2022_2034046 crossref_primary_10_1007_s11357_021_00355_9 crossref_primary_10_4103_1673_5374_320995 |
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| Copyright | Copyright © 2018 Shao, Cao, Bai, Huang, Wang, Sun, Gan, Ye, Yin, Zhang, Gu, Hu, Bai and Yan. 2018 Shao, Cao, Bai, Huang, Wang, Sun, Gan, Ye, Yin, Zhang, Gu, Hu, Bai and Yan |
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| Keywords | clinical outcomes gender difference interaction effect mild traumatic brain injury cortical thickness |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Edited by: Nada Andelic, Oslo University Hospital, Norway These authors have contributed equally to this work This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology Reviewed by: Paul Perrin, Virginia Commonwealth University, United States; Rao P. Gullapalli, University of Maryland, United States |
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| Title | Preliminary Evidence of Sex Differences in Cortical Thickness Following Acute Mild Traumatic Brain Injury |
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