Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans

[Display omitted] •The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using the synthetic route of childinin E.•The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an ant...

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Published inTetrahedron letters Vol. 61; no. 49; pp. 152588 - 152591
Main Authors Kamauchi, Hitoshi, Hirata, Momoka, Takao, Koichi, Sugita, Yoshiaki
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier Ltd 03.12.2020
Elsevier
Subjects
Benzophenone
Candida albicans
Chemistry
Chemistry, Organic
Daldinia spp
Hyphal formation
Physical Sciences
Science & Technology
Candida albicans
Daldinia spp
Hyphal formation
Benzophenone
TRANSITION
FUNGUS
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Abstract [Display omitted] •The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using the synthetic route of childinin E.•The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti- hyphal formation test.•Anti-hyphal formation activity of benzophenone derivatives was evaluated.•Childnin E and two derivatives exhibited anti-hyphal formation activity. The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity.
AbstractList The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity. (C) 2020 Elsevier Ltd. All rights reserved.
[Display omitted] •The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using the synthetic route of childinin E.•The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti- hyphal formation test.•Anti-hyphal formation activity of benzophenone derivatives was evaluated.•Childnin E and two derivatives exhibited anti-hyphal formation activity. The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity.
ArticleNumber 152588
Author Sugita, Yoshiaki
Kamauchi, Hitoshi
Hirata, Momoka
Takao, Koichi
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Issue 49
Keywords Candida albicans
Daldinia spp
Hyphal formation
Benzophenone
TRANSITION
FUNGUS
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References Braun, Johnson (b0060) 2000; 155
Quang, Harinantenaina, Nishizawa, Hashimoto, Kohchi, Soma, Asakawa (b0015) 2006; 60
Jackson, Yang, Wu, Kennelly, Lipke (b0025) 2015; 59
Naseem, Gunasekera, Araya, Konopka (b0055) 2011; 286
Lindsay, Deveau, Piispanen, Hogan (b0035) 2012; 11
Nazih, Benezra, Lepoittevin (b0050) 1993; 6
Hashimoto, Tahara, Takaoka, Tori, Asakawa (b0005) 1994; 42
Toenjes, Munsee, Ibrahim, Jeffrey, Edwards, Johnson (b0030) 2005; 49
Wang, Wang, Wang, Li, Huang, Li (b0045) 2015; 58
Cueto, Jensen, Kauffman, Fenical, Lobkovsky, Clardy (b0020) 2001; 64
Sinhababu, Borchardt (b0040) 1983; 13
Zhao, Chen, Huang, Zhang, Li, Feng, Liu (b0010) 2017; 142
Lindsay, AK (WOS:000309524800005) 2012; 11
Zhao, ZZ (WOS:000408784800008) 2017; 142
SINHABABU, AK (WOS:A1983RA61300009) 1983; 13
Cueto, M (WOS:000172496200012) 2001; 64
Quang, DN (WOS:000202948000005) 2006; 60
Braun, BR (WOS:000086869200006) 2000; 155
Jackson, DN (WOS:000367591800020) 2015; 59
HASHIMOTO, T (WOS:A1994NY51300027) 1994; 42
Wang, ZR (WOS:000364796100021) 2015; 58
Naseem, S (WOS:000293837000004) 2011; 286
Toenjes, KA (WOS:000227339500013) 2005; 49
NAZIH, A (WOS:A1993KT72100011) 1993; 6
Lindsay (10.1016/j.tetlet.2020.152588_b0035) 2012; 11
Cueto (10.1016/j.tetlet.2020.152588_b0020) 2001; 64
Quang (10.1016/j.tetlet.2020.152588_b0015) 2006; 60
Jackson (10.1016/j.tetlet.2020.152588_b0025) 2015; 59
Zhao (10.1016/j.tetlet.2020.152588_b0010) 2017; 142
Nazih (10.1016/j.tetlet.2020.152588_b0050) 1993; 6
Hashimoto (10.1016/j.tetlet.2020.152588_b0005) 1994; 42
Sinhababu (10.1016/j.tetlet.2020.152588_b0040) 1983; 13
Braun (10.1016/j.tetlet.2020.152588_b0060) 2000; 155
Naseem (10.1016/j.tetlet.2020.152588_b0055) 2011; 286
Toenjes (10.1016/j.tetlet.2020.152588_b0030) 2005; 49
Wang (10.1016/j.tetlet.2020.152588_b0045) 2015; 58
References_xml – volume: 6
  start-page: 215
  year: 1993
  end-page: 222
  ident: b0050
  publication-title: Chem. Res. Toxicol.
  contributor:
    fullname: Lepoittevin
– volume: 64
  start-page: 1444
  year: 2001
  end-page: 1446
  ident: b0020
  publication-title: J. Nat. Prod.
  contributor:
    fullname: Clardy
– volume: 11
  start-page: 1219
  year: 2012
  end-page: 1225
  ident: b0035
  publication-title: Eukaryot Cell.
  contributor:
    fullname: Hogan
– volume: 286
  start-page: 28671
  year: 2011
  end-page: 28680
  ident: b0055
  publication-title: J. Biol. Chem.
  contributor:
    fullname: Konopka
– volume: 13
  start-page: 677
  year: 1983
  end-page: 683
  ident: b0040
  publication-title: Synth. Commun.
  contributor:
    fullname: Borchardt
– volume: 59
  start-page: 6032
  year: 2015
  end-page: 6038
  ident: b0025
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Lipke
– volume: 155
  start-page: 57
  year: 2000
  end-page: 67
  ident: b0060
  publication-title: Genetics
  contributor:
    fullname: Johnson
– volume: 49
  start-page: 963
  year: 2005
  end-page: 972
  ident: b0030
  publication-title: Antimicrob. Agents Chemother.
  contributor:
    fullname: Johnson
– volume: 58
  start-page: 8616
  year: 2015
  end-page: 8637
  ident: b0045
  publication-title: J. Med. Chem.
  contributor:
    fullname: Li
– volume: 42
  start-page: 1528
  year: 1994
  end-page: 1530
  ident: b0005
  publication-title: Chem. Pharm. Bull.
  contributor:
    fullname: Asakawa
– volume: 142
  start-page: 68
  year: 2017
  end-page: 75
  ident: b0010
  publication-title: Phytochemistry.
  contributor:
    fullname: Liu
– volume: 60
  start-page: 303
  year: 2006
  end-page: 307
  ident: b0015
  publication-title: J. Nat. Med.
  contributor:
    fullname: Asakawa
– volume: 49
  start-page: 963
  year: 2005
  ident: WOS:000227339500013
  article-title: Small-molecule inhibitors of the budded-to-hyphal-form transition in the pathogenic yeast Candida albicans
  publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  doi: 10.1128/AAC.49.3.963-972.2005
  contributor:
    fullname: Toenjes, KA
– volume: 58
  start-page: 8616
  year: 2015
  ident: WOS:000364796100021
  article-title: Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer's Disease
  publication-title: JOURNAL OF MEDICINAL CHEMISTRY
  doi: 10.1021/acs.jmedchem.5b01222
  contributor:
    fullname: Wang, ZR
– volume: 59
  start-page: 6032
  year: 2015
  ident: WOS:000367591800020
  article-title: Garcinia xanthochymus Benzophenones Promote Hyphal Apoptosis and Potentiate Activity of Fluconazole against Candida albicans Biofilms
  publication-title: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
  doi: 10.1128/AAC.00820-15
  contributor:
    fullname: Jackson, DN
– volume: 42
  start-page: 1528
  year: 1994
  ident: WOS:A1994NY51300027
  article-title: STRUCTURES OF A NOVEL BINAPHTHYL AND 3 NOVEL BENZOPHENONE DERIVATIVES WITH PLANT-GROWTH INHIBITORY ACTIVITY FROM THE FUNGUS DALDINIA-CONCENTRICA
  publication-title: CHEMICAL & PHARMACEUTICAL BULLETIN
  contributor:
    fullname: HASHIMOTO, T
– volume: 286
  start-page: 28671
  year: 2011
  ident: WOS:000293837000004
  article-title: N-Acetylglucosamine (GlcNAc) Induction of Hyphal Morphogenesis and Transcriptional Responses in Candida albicans Are Not Dependent on Its Metabolism
  publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY
  doi: 10.1074/jbc.M111.249854
  contributor:
    fullname: Naseem, S
– volume: 142
  start-page: 68
  year: 2017
  ident: WOS:000408784800008
  article-title: Bioactive polyketides and 8,14-seco-ergosterol from fruiting bodies of the ascomycete Daldinia childiae
  publication-title: PHYTOCHEMISTRY
  doi: 10.1016/j.phytochem.2017.06.020
  contributor:
    fullname: Zhao, ZZ
– volume: 13
  start-page: 677
  year: 1983
  ident: WOS:A1983RA61300009
  article-title: SELECTIVE RING C-METHYLATION OF HYDROXYBENZALDEHYDES VIA THEIR MANNICH-BASES
  publication-title: SYNTHETIC COMMUNICATIONS
  contributor:
    fullname: SINHABABU, AK
– volume: 64
  start-page: 1444
  year: 2001
  ident: WOS:000172496200012
  article-title: Pestalone, a new antibiotic produced by a marine fungus in response to bacterial challenge
  publication-title: JOURNAL OF NATURAL PRODUCTS
  doi: 10.1021/np0102713
  contributor:
    fullname: Cueto, M
– volume: 11
  start-page: 1219
  year: 2012
  ident: WOS:000309524800005
  article-title: Farnesol and Cyclic AMP Signaling Effects on the Hypha-to-Yeast Transition in Candida albicans
  publication-title: EUKARYOTIC CELL
  doi: 10.1128/EC.00144-12
  contributor:
    fullname: Lindsay, AK
– volume: 155
  start-page: 57
  year: 2000
  ident: WOS:000086869200006
  article-title: TUP1, CPH1 and EFG1 make independent contributions to filamentation in Candida albicans
  publication-title: GENETICS
  contributor:
    fullname: Braun, BR
– volume: 6
  start-page: 215
  year: 1993
  ident: WOS:A1993KT72100011
  article-title: BIHAPTENS WITH 5-METHYL-SUBSTITUTED AND 6-METHYL-SUBSTITUTED ALKYLCATECHOLS AND METHYLENE LACTONE FUNCTIONAL-GROUPS - TOOLS FOR HAPTEN (ALLERGEN OR TOLEROGEN) PROTEIN-INTERACTION STUDIES
  publication-title: CHEMICAL RESEARCH IN TOXICOLOGY
  contributor:
    fullname: NAZIH, A
– volume: 60
  start-page: 303
  year: 2006
  ident: WOS:000202948000005
  article-title: Inhibitory activity of nitric oxide production in RAW 264.7 cells of daldinals A-C from the fungus Daldinia childiae and other metabolites isolated from inedible mushrooms
  publication-title: JOURNAL OF NATURAL MEDICINES
  doi: 10.1007/s11418-006-0010-1
  contributor:
    fullname: Quang, DN
– volume: 58
  start-page: 8616
  year: 2015
  ident: 10.1016/j.tetlet.2020.152588_b0045
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.5b01222
  contributor:
    fullname: Wang
– volume: 42
  start-page: 1528
  year: 1994
  ident: 10.1016/j.tetlet.2020.152588_b0005
  publication-title: Chem. Pharm. Bull.
  doi: 10.1248/cpb.42.1528
  contributor:
    fullname: Hashimoto
– volume: 64
  start-page: 1444
  year: 2001
  ident: 10.1016/j.tetlet.2020.152588_b0020
  publication-title: J. Nat. Prod.
  doi: 10.1021/np0102713
  contributor:
    fullname: Cueto
– volume: 59
  start-page: 6032
  year: 2015
  ident: 10.1016/j.tetlet.2020.152588_b0025
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.00820-15
  contributor:
    fullname: Jackson
– volume: 155
  start-page: 57
  year: 2000
  ident: 10.1016/j.tetlet.2020.152588_b0060
  publication-title: Genetics
  doi: 10.1093/genetics/155.1.57
  contributor:
    fullname: Braun
– volume: 142
  start-page: 68
  year: 2017
  ident: 10.1016/j.tetlet.2020.152588_b0010
  publication-title: Phytochemistry.
  doi: 10.1016/j.phytochem.2017.06.020
  contributor:
    fullname: Zhao
– volume: 13
  start-page: 677
  year: 1983
  ident: 10.1016/j.tetlet.2020.152588_b0040
  publication-title: Synth. Commun.
  doi: 10.1080/00397918308060349
  contributor:
    fullname: Sinhababu
– volume: 49
  start-page: 963
  year: 2005
  ident: 10.1016/j.tetlet.2020.152588_b0030
  publication-title: Antimicrob. Agents Chemother.
  doi: 10.1128/AAC.49.3.963-972.2005
  contributor:
    fullname: Toenjes
– volume: 60
  start-page: 303
  year: 2006
  ident: 10.1016/j.tetlet.2020.152588_b0015
  publication-title: J. Nat. Med.
  doi: 10.1007/s11418-006-0010-1
  contributor:
    fullname: Quang
– volume: 6
  start-page: 215
  year: 1993
  ident: 10.1016/j.tetlet.2020.152588_b0050
  publication-title: Chem. Res. Toxicol.
  doi: 10.1021/tx00032a011
  contributor:
    fullname: Nazih
– volume: 286
  start-page: 28671
  year: 2011
  ident: 10.1016/j.tetlet.2020.152588_b0055
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.249854
  contributor:
    fullname: Naseem
– volume: 11
  start-page: 1219
  year: 2012
  ident: 10.1016/j.tetlet.2020.152588_b0035
  publication-title: Eukaryot Cell.
  doi: 10.1128/EC.00144-12
  contributor:
    fullname: Lindsay
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Snippet [Display omitted] •The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using...
The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of...
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elsevier
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StartPage 152588
SubjectTerms Benzophenone
Candida albicans
Chemistry
Chemistry, Organic
Daldinia spp
Hyphal formation
Physical Sciences
Science & Technology
Title Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans
URI https://dx.doi.org/10.1016/j.tetlet.2020.152588
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