Synthesis and pharmacological evaluation of childinin E and several derivatives as anti-hyphal formation inhibitors against Candida albicans
[Display omitted] •The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using the synthetic route of childinin E.•The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an ant...
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Published in | Tetrahedron letters Vol. 61; no. 49; pp. 152588 - 152591 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
03.12.2020
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | [Display omitted]
•The first total synthesis of childinin E was achieved from the commercial benzaldehyde.•Five benzophenone derivatives were obtained by using the synthetic route of childinin E.•The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti- hyphal formation test.•Anti-hyphal formation activity of benzophenone derivatives was evaluated.•Childnin E and two derivatives exhibited anti-hyphal formation activity.
The natural highly substituted benzophenone childinin E (1) was previously isolated from the fungus Daldinia childiae. Here we describe the total synthesis of childinin E and several derivatives using a linear seven-step sequence. The antifungal properties of the synthesized compounds against Candida albicans were evaluated by an anti-hyphal formation test. Childnin E and two derivatives exhibited anti-hyphal formation activity. |
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ISSN: | 0040-4039 1873-3581 |
DOI: | 10.1016/j.tetlet.2020.152588 |