The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

• Published in: Oncotarget Vol. 6; no. 26; pp. 22513 - 22525
• Main Authors: Liang, Wei-Cheng, Fu, Wei-Ming, Wong, Cheuk-Wa, Wang, Yan, Wang, Wei-Mao, Hu, Guo-Xin, Zhang, Li, Xiao, Li-Jia, Wan, David Chi-Cheong, Zhang, Jin-Fang, Waye, Mary Miu-Yee
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 08.09.2015
• Subjects: Animals; Colorectal Neoplasms - genetics; Colorectal Neoplasms - metabolism; Colorectal Neoplasms - pathology; Epithelial-Mesenchymal Transition - genetics; HCT116 Cells; HEK293 Cells; Heterografts; HT29 Cells; Humans; Mice; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; Research Paper; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Up-Regulation; ceRNA; lncRNA; miRNA sponges

Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic gene in multiple cancer types and elevated expression of H19 was tightly linked to tumorigenesis and cancer progression. However, the molecular basis for this observation has not been characterized in colorectal cance...