Inhibition of Tyrosinase by Mercury Chloride: Spectroscopic and Docking Studies

• Published in: Frontiers in pharmacology Vol. 11; p. 81
• Main Authors: Chen, Jianmin, Ye, Yaling, Ran, Mengnan, Li, Qinglian, Ruan, Zhipeng, Jin, Nan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.03.2020
• Subjects: inhibition mechanism; mercury chloride; molecular docking; Pharmacology; spectroscopic measurements; tyrosinase; inhibition mechanism; molecular docking; mercury chloride; tyrosinase; spectroscopic measurements

Inorganic mercury compounds have been used in skin-lightening products since ancient times. Although a previous study demonstrated that mercury impeded the transfer of Cu to the apotyrosinase, the effect of mercury on tyrosinase is still unclear. In the present study, the mechanism of mercury chlori...