The Role of Sirt6 in Obesity and Diabetes

• Published in: Frontiers in physiology Vol. 9; p. 135
• Main Authors: Kuang, Jiangying, Chen, Lei, Tang, Qin, Zhang, Jinhang, Li, Yanping, He, Jinhan
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.02.2018
• Subjects: diabetes mellitus; gluconeogenesis; LiPo; obesity; Physiology; Sirt6; type 2; LiPo; diabetes mellitus; type 2; Sirt6; gluconeogenesis; obesity

Sirt6 is one of the sirtuin family members, a kind of NAD+-dependent histone deacetylase and ADP-ribose transferase enzyme. It has an important role in physiological and pathological processes, regulating aging, cancer, obesity, insulin resistance, inflammation, and energy metabolism. Recent studies...