Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways
Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the trans...
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| Published in | Frontiers in immunology Vol. 9; p. 1849 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
Switzerland
Frontiers Media S.A
09.08.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways. Thus, TRAFs possess important and complex signaling functions in the immune system and play an important role in regulating immune and inflammatory responses. This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways. |
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| AbstractList | Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways. Thus, TRAFs possess important and complex signaling functions in the immune system and play an important role in regulating immune and inflammatory responses. This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways. Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways. Thus, TRAFs possess important and complex signaling functions in the immune system and play an important role in regulating immune and inflammatory responses. This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways.Tumor necrosis factor receptor (TNFR)-associated factors (TRAFs) are a family of structurally related proteins that transduces signals from members of TNFR superfamily and various other immune receptors. Major downstream signaling events mediated by the TRAF molecules include activation of the transcription factor nuclear factor κB (NF-κB) and the mitogen-activated protein kinases (MAPKs). In addition, some TRAF family members, particularly TRAF2 and TRAF3, serve as negative regulators of specific signaling pathways, such as the noncanonical NF-κB and proinflammatory toll-like receptor pathways. Thus, TRAFs possess important and complex signaling functions in the immune system and play an important role in regulating immune and inflammatory responses. This review will focus on the role of TRAF proteins in the regulation of NF-κB and MAPK signaling pathways. |
| Author | Sun, Shao-Cong Shi, Jian-Hong |
| AuthorAffiliation | 1 Central Laboratory, Affiliated Hospital of Hebei University , Baoding , China 2 Department of Immunology, The University of Texas MD Anderson Cancer Center , Houston, TX , United States |
| AuthorAffiliation_xml | – name: 1 Central Laboratory, Affiliated Hospital of Hebei University , Baoding , China – name: 2 Department of Immunology, The University of Texas MD Anderson Cancer Center , Houston, TX , United States |
| Author_xml | – sequence: 1 givenname: Jian-Hong surname: Shi fullname: Shi, Jian-Hong – sequence: 2 givenname: Shao-Cong surname: Sun fullname: Sun, Shao-Cong |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30140268$$D View this record in MEDLINE/PubMed |
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| IngestDate | Wed Aug 27 01:32:04 EDT 2025 Thu Aug 21 14:07:02 EDT 2025 Thu Jul 10 21:15:28 EDT 2025 Thu Apr 03 07:09:15 EDT 2025 Thu Apr 24 22:56:57 EDT 2025 Tue Jul 01 01:35:30 EDT 2025 |
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| Keywords | tumor necrosis factor receptor-associated factor nuclear factor κB tumor necrosis factor receptors toll-like receptors inflammation mitogen-activated protein kinases |
| Language | English |
| License | This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Specialty section: This article was submitted to Molecular Innate Immunity, a section of the journal Frontiers in Immunology Reviewed by: Hasem Habelhah, University of Iowa, United States; Ping Xie, Rutgers University, The State University of New Jersey, United States; Weizhou Zhang, University of Iowa, United States Edited by: Gail Abendroth Bishop, University of Iowa, United States |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.3389/fimmu.2018.01849 |
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| PublicationDate | 2018-08-09 |
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| PublicationTitle | Frontiers in immunology |
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| PublicationYear | 2018 |
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| SubjectTerms | Animals Humans Immunology inflammation Inflammation - metabolism Inflammation Mediators - metabolism mitogen-activated protein kinases Mitogen-Activated Protein Kinases - metabolism NF-kappa B - metabolism nuclear factor κB Signal Transduction TNF Receptor-Associated Factor 2 - metabolism TNF Receptor-Associated Factor 3 - metabolism TNF Receptor-Associated Factor 6 - metabolism toll-like receptors tumor necrosis factor receptor-associated factor Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism tumor necrosis factor receptors |
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| Title | Tumor Necrosis Factor Receptor-Associated Factor Regulation of Nuclear Factor κB and Mitogen-Activated Protein Kinase Pathways |
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