Disposition of propargyl alcohol in rat and mouse after intravenous, oral, dermal and inhalation exposure

• Published in: Xenobiotica Vol. 31; no. 6; pp. 357 - 375
• Main Authors: Dix, K. J., Coleman, D. P., Fossett, J. E., Gaudette, N. F., Stanley, A. P., Thomas, B. F., Jeffcoat, A. R.
• Format: Journal Article
• Language: English
• Published: London Informa UK Ltd 01.06.2001; Taylor & Francis
• Subjects: Administration, Cutaneous; Administration, Inhalation; Administration, Oral; Alkynes - administration & dosage; Alkynes - pharmacokinetics; Alkynes - urine; Animals; Bile - metabolism; Biological and medical sciences; Breath Tests; Carbon Radioisotopes; Chemical and industrial products toxicology. Toxic occupational diseases; Chromatography, High Pressure Liquid; Feces; Injections, Intravenous; Kinetics; Male; Mass Spectrometry; Medical sciences; Mice; Propanols - administration & dosage; Propanols - pharmacokinetics; Propanols - urine; propargyl alcohol; Rats; Rats, Inbred F344; Tissue Distribution; Toxicology; Various organic compounds; Intravenous administration; Rat; Rodentia; Oral administration; Metabolism; Inhalation; Percutaneous route; Toxicokinetics; Vertebrata; Mammalia; Mouse; Animal; Distribution; Pharmacokinetics

1. The disposition of propargyl alcohol (PAL) radiolabelled with carbon-14 ([2,3- 14C]PAL) was determined in the F344 rat and B6C3F1 mouse following intravenous (i.v.), oral, inhalation and dermal exposure. 2. By 72 h following an i.v. (1 mg kg -1) or oral (50 mg kg-1) dose, 76-90% of the dose was e...