Network Rewiring in Cancer: Applications to Melanoma Cell Lines and the Cancer Genome Atlas Patients

• Published in: Frontiers in genetics Vol. 9; p. 228
• Main Authors: Ding, Kuan-Fu, Finlay, Darren, Yin, Hongwei, Hendricks, William P D, Sereduk, Chris, Kiefer, Jeffrey, Sekulic, Aleksandar, LoRusso, Patricia M, Vuori, Kristiina, Trent, Jeffrey M, Schork, Nicholas J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.07.2018
• Subjects: bioinformatics and computational biology; drug interactions; Genetics; machine learning; melanoma; network rewiring; pathway analysis; simulation models; drug interactions; data science; bioinformatics and computational biology; melanoma; network rewiring; machine learning; pathway analysis

Genes do not work in isolation, but rather as part of networks that have many feedback and redundancy mechanisms. Studying the properties of genetic networks and how individual genes contribute to overall network functions can provide insight into genetically-mediated disease processes. Most analyti...