Concentric and Eccentric Endurance Exercise Reverse Hallmarks of T-Cell Senescence in Pre-diabetic Subjects

• Published in: Frontiers in physiology Vol. 10; p. 684
• Main Authors: Philippe, Marc, Gatterer, Hannes, Burtscher, Martin, Weinberger, Birgit, Keller, Michael, Grubeck-Loebenstein, Beatrix, Fleckenstein, Johannes, Alack, Katharina, Krüger, Karsten
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.06.2019
• Subjects: concentric exercise; eccentric exercise; inflammation; naïve T-cells; Physiology; TEMRA cells; concentric exercise; eccentric exercise; TEMRA cells; naïve T-cells; inflammation

The peripheral T-cell pool undergoes a striking age associated remodeling which is accelerated by progressive insulin resistance. Exercise training is known to delay several aspects of T-cell senescence. The purpose of the current study was to investigate the effect of 3 weeks regular concentric or...