Gene–Dose Effect of MEFV Gain-of-Function Mutations Determines ex vivo Neutrophil Activation in Familial Mediterranean Fever - Stoler, Iris; Freytag, Judith; Orak, Banu; Unterwalder, Nadine; Henning, Stephan; Heim, Katrin; von Bernuth, Horst; Krüger, Renate; Winkler, Stefan; Eschenhagen, Patience; Seipelt, Eva; Mall, Marcus A.; et al. (Frontiers in immunology, 2020)
Keywords: Adolescent; Adult; Aged; Aged, 80 and over; autoinflammation; Caspase 1 - blood; Cells, Cultured; Child; Cohort Studies; familial mediterranean fever; Familial Mediterranean Fever - blood; Familial Mediterranean Fever - genetics; Familial Mediterranean Fever - immunology; Female; Gain of Function Mutation; Gene Dosage; Heterozygote; Humans; IL-18; Immunology; Interleukin-18 - blood; Male; Middle Aged; Neutrophil; Neutrophil Activation; Neutrophils - immunology; Phenotype; Pyrin - genetics; S100A12; S100A12 Protein - blood; Young Adult; autoinflammation; S100A12; Neutrophil; IL-18; familial mediterranean fever