Radiosensitization in Pediatric High-Grade Glioma: Targets, Resistance and Developments

• Published in: Frontiers in oncology Vol. 11; p. 662209
• Main Authors: Metselaar, Dennis S, du Chatinier, Aimée, Stuiver, Iris, Kaspers, Gertjan J L, Hulleman, Esther
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.04.2021
• Subjects: glioma; Oncology; pediatric high-grade glioma (pHGG); radio-enhancement; radioresistance; radiosensitizer; radiotherapy; radiotherapy; glioma; pediatric high-grade glioma (pHGG); radio-enhancement; radiosensitizer; radioresistance

Pediatric high-grade gliomas (pHGG) are the leading cause of cancer-related death in children. These epigenetically dysregulated tumors often harbor mutations in genes encoding , which contributes to a stem cell-like, therapy-resistant phenotype. Furthermore, pHGG are characterized by a diffuse grow...