Small sample sizes: A big data problem in high-dimensional data analysis

• Published in: Statistical methods in medical research Vol. 30; no. 3; pp. 687 - 701
• Main Authors: Konietschke, Frank, Schwab, Karima, Pauly, Markus
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.03.2021
• Subjects: Multiple contrast tests; max t-test; simultaneous confidence intervals; resampling; repeated measures

In many experiments and especially in translational and preclinical research, sample sizes are (very) small. In addition, data designs are often high dimensional, i.e. more dependent than independent replications of the trial are observed. The present paper discusses the applicability of max t-test-...