Evidence that the endometrial microbiota has an effect on implantation success or failure

• Published in: American journal of obstetrics and gynecology Vol. 215; no. 6; pp. 684 - 703
• Main Authors: Moreno, Inmaculada, Codoñer, Francisco M., Vilella, Felipe, Valbuena, Diana, Martinez-Blanch, Juan F., Jimenez-Almazán, Jorge, Alonso, Roberto, Alamá, Pilar, Remohí, Jose, Pellicer, Antonio, Ramon, Daniel, Simon, Carlos
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.12.2016
• Subjects: assisted reproductive techniques; bacterial pathogens; Bacterial Typing Techniques; Case-Control Studies; Embryo Implantation; Embryo Transfer; endometrial microbiota; endometrial receptivity array; Endometrium - microbiology; Female; Fertilization in Vitro; Gardnerella vaginalis - genetics; Genome, Bacterial; Humans; Infertility - therapy; Lactobacillus - genetics; Live Birth - epidemiology; Logistic Models; Luteinizing Hormone; Menstrual Cycle; Microbiota - genetics; Multivariate Analysis; Obstetrics and Gynecology; Pilot Projects; Polymerase Chain Reaction; Pregnancy; Pregnancy Rate; Prevotella - genetics; Principal Component Analysis; Prospective Studies; RNA, Ribosomal, 16S - genetics; Sequence Analysis, RNA; Spain - epidemiology; Treatment Outcome; Vagina - microbiology; bacterial pathogens; endometrial microbiota; embryo implantation; endometrial receptivity array; assisted reproductive techniques

Bacterial cells in the human body account for 1–3% of total body weight and are at least equal in number to human cells. Recent research has focused on understanding how the different bacterial communities in the body (eg, gut, respiratory, skin, and vaginal microbiomes) predispose to health and dis...