Osteopontin and LDLR Are Upregulated in Hearts of Sudden Cardiac Death Victims With Heart Failure With Preserved Ejection Fraction and Diabetes Mellitus

• Published in: Frontiers in cardiovascular medicine Vol. 7; p. 610282
• Main Authors: Patel, Mausam, Rodriguez, Daniela, Yousefi, Keyvan, John-Williams, Krista, Mendez, Armando J., Goldberg, Ronald B., Lymperopoulos, Anastasios, Tamariz, Leonardo J., Goldberger, Jeffrey J., Myerburg, Robert J., Junttila, Juhani, Shehadeh, Lina A.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 30.11.2020
• Subjects: Cardiovascular Medicine; diabetes mellilus; HFpEF—heart failure with preserved ejection fraction; LDLR; osteopontin (OPN); sudden cardiac death (SCD); HFpEF—heart failure with preserved ejection fraction; osteopontin (OPN); diabetes mellilus; sudden cardiac death (SCD); LDLR

Background: Diabetes mellitus (DM) is associated with increased risk of sudden cardiac death (SCD), particularly in patients with heart failure with preserved ejection fraction (HFpEF). However, there are no known biomarkers in the population with DM and HFpEF to predict SCD risk. Objectives: This s...