Identification and elimination of an immunodominant T-cell epitope in recombinant immunotoxins based on Pseudomonas exotoxin A - Mazor, Ronit; Vassall, Aaron N.; Eberle, Jaime A.; Beers, Richard; Weldon, John E.; Venzon, David J.; Tsang, Kwong Y.; Benhar, Itai; Pastan, Ira (Proceedings of the National Academy of Sciences - PNAS, 2012)
Keywords: ADP Ribose Transferases - chemistry; alanine; alleles; Amino acids; Antibodies - chemistry; antibody formation; Bacterial proteins; bacterial toxins; Bacterial Toxins - chemistry; Biological Sciences; CD4-Positive T-Lymphocytes - cytology; Correlation analysis; cytotoxicity; Enzyme-Linked Immunosorbent Assay - methods; Epitopes - chemistry; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; exotoxins; Exotoxins - chemistry; Gene Deletion; Genetic Variation; Humans; Immune System; immunodominant epitopes; Immunotoxins; interleukin-2; Interleukin-2 - metabolism; Leukocytes, Mononuclear - cytology; Molecular Conformation; mutants; neoplasms; neutralizing antibodies; patients; Peptides - chemistry; PNAS Plus; Protein Binding; Protein Conformation; Protein Engineering - methods; Protein Structure, Tertiary; Proteins; Pseudomonas; Pseudomonas aeruginosa Exotoxin A; recombinant fusion proteins; T cell receptors; T-lymphocytes; therapeutics; Toxins; Virulence Factors - chemistry