RelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells

• Published in: Frontiers in oncology Vol. 12; p. 826617
• Main Authors: Mijit, Mahmut, Wireman, Randall, Armstrong, Lee, Gampala, Silpa, Hassan, Zonera, Schneeweis, Christian, Schneider, Guenter, Zhang, Chi, Fishel, Melissa L., Kelley, Mark R.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 24.03.2022
• Subjects: Ape1; DNA repair; Oncology; pancreatic ductal adenocarcinoma (PDAC); redox signaling; relA; transcriptional factors; redox signaling; Ape1; pancreatic ductal adenocarcinoma (PDAC); PRDX1; STAT3; transcriptional factors; DNA repair; relA

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers with a poor response to current treatment regimens. The multifunctional DNA repair-redox signaling protein Ref-1 has a redox signaling function that activates several transcriptional factors (TFs) including NF-κB (RelA), STAT3,...