Step-Up Approach for Sodium Butyrate Treatment in Children With Congenital Chloride Diarrhea

• Published in: Frontiers in pediatrics Vol. 9; p. 810765
• Main Authors: Di Meglio, Lavinia, Grimaldi, Giusi, Esposito, Francesco, Gelzo, Monica, Esposito, Maria Valeria, Castaldo, Giuseppe, Canani, Roberto Berni
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.01.2022
• Subjects: butyrate; COEDS; congenital chloride diarrhea; congenital diarrheal disorders; Pediatrics; SLC26A3; butyrate; congenital chloride diarrhea; COEDS; SLC26A3; congenital diarrheal disorders

Oral salt substitutive therapy is pivotal for the survival of patients with congenital chloride diarrhea (CLD), however this therapy is unable to influence the symptoms severity. Butyrate has been proposed to limit diarrhea severity in CLD. Unfortunately, the optimal dose schedule is still largely u...