Monocyte Chemoattractant Protein 1 Promotes VEGF-A Expression in OSCC by Activating ILK and MEK1/2 Signaling and Downregulating miR-29c

• Published in: Frontiers in oncology Vol. 10; p. 592415
• Main Authors: Lien, Ming-Yu, Chang, An-Chen, Tsai, Hsiao-Chi, Tsai, Ming-Hsui, Hua, Chun-Hung, Cheng, Shih-Ping, Wang, Shih-Wei, Tang, Chih-Hsin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.11.2020
• Subjects: angiogenesis; miR-29c; monocyte chemoattractant protein-1; Oncology; oral squamous cell carcinoma; vascular endothelial growth factor A; monocyte chemoattractant protein-1; miR-29c; oral squamous cell carcinoma; vascular endothelial growth factor A; angiogenesis

Oral squamous cell carcinoma (OSCC) is an aggressive tumor that has a poor prognosis, with high levels of local invasion and lymph node metastasis. Vascular endothelial growth factor A (VEGF-A) plays essential roles in OSCC tumor angiogenesis and metastasis. Monocyte chemoattractant protein-1 (MCP-1...