Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins

• Published in: Oncotarget Vol. 6; no. 26; pp. 22949 - 22958
• Main Authors: Wang, Yihong, Schwartz, Lauren Ende, Anderson, Derek, Lin, Ming-Tseh, Haley, Lisa, Wu, Ren-Chin, Vang, Russell, Shih, Ie-Ming, Kurman, Robert J
• Format: Journal Article
• Language: English
• Published: United States Impact Journals LLC 08.09.2015
• Subjects: Adenocarcinoma, Mucinous - genetics; Adenocarcinoma, Mucinous - pathology; Adolescent; Adult; Aged; Carcinoma, Ovarian Epithelial; Cohort Studies; Female; Humans; Middle Aged; Neoplasms, Glandular and Epithelial - genetics; Neoplasms, Glandular and Epithelial - pathology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - pathology; Research Paper; Teratoma - genetics; Teratoma - pathology; Young Adult; HUMARA assay; teratoma; mucinous carcinoma; ovarian; microsatellite genotyping

It is believed that a subset of primary ovarian mucinous tumors is derived from mature teratomas [1-5]. To confirm this, we performed microsatellite genotyping using a variety of short tandem repeat makers and analyzed allelotypes of 8 mucinous tumors (4 mucinous carcinomas, 3 atypical proliferative...