Identification of Novel MeCP2 Cancer-Associated Target Genes and Post-Translational Modifications

• Published in: Frontiers in oncology Vol. 10; p. 576362
• Main Authors: Castro-Piedras, Isabel, Vartak, David, Sharma, Monica, Pandey, Somnath, Casas, Laura, Molehin, Deborah, Rasha, Fahmida, Fokar, Mohamed, Nichols, Jacob, Almodovar, Sharilyn, Rahman, Rakhshanda Layeequr, Pruitt, Kevin
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 10.12.2020
• Subjects: breast cancer; ChIP-Seq analysis; MeCP2; Oncology; post-translational modification; transcriptional regulation; MeCP2; breast cancer; post-translational modification; ChIP-Seq analysis; transcriptional regulation

Abnormal regulation of DNA methylation and its readers has been associated with a wide range of cellular dysfunction. Disruption of the normal function of DNA methylation readers contributes to cancer progression, neurodevelopmental disorders, autoimmune disease and other pathologies. One reader of...