Genotypic Characteristics of Hepatoblastoma as Detected by Next Generation Sequencing and Their Correlation With Clinical Efficacy

• Published in: Frontiers in oncology Vol. 11; p. 628531
• Main Authors: Hu, Huimin, Zhang, Weiling, Zhi, Tian, Li, Jing, Wen, Yuan, Li, Fan, Mei, Yanyan, Huang, Dongsheng
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 06.08.2021
• Subjects: CTNNB1; hepatoblastoma; next generation sequencing; Oncology; PDL1; tumor mutation burden; hepatoblastoma; CTNNB1; PDL1; tumor mutation burden; next generation sequencing

Hepatoblastoma (HB) is the most common malignant embryonic liver tumor type in children under 3 years of age. In the present study, the next generation sequencing (NGS) method was used to detect the genotype characteristics of HB and summarize the correlation between the common mutation genotypes no...