Tripartite ATP-Independent Periplasmic (TRAP) Transporters and Tripartite Tricarboxylate Transporters (TTT): From Uptake to Pathogenicity

• Published in: Frontiers in cellular and infection microbiology Vol. 8; p. 33
• Main Authors: Rosa, Leonardo T, Bianconi, Matheus E, Thomas, Gavin H, Kelly, David J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.02.2018
• Subjects: Adenosine Triphosphate - metabolism; ATP-Binding Cassette Transporters - chemistry; ATP-Binding Cassette Transporters - genetics; ATP-Binding Cassette Transporters - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological Transport; carboxylic acids; high-affinity; Membrane Transport Proteins - chemistry; Membrane Transport Proteins - genetics; Membrane Transport Proteins - metabolism; Microbiology; Multigene Family; periplasmic binding-proteins; Protein Binding; Protein Subunits; secondary transporter; solute transport; Structure-Activity Relationship; Virulence; solute transport; secondary transporter; high-affinity; periplasmic binding-proteins; carboxylic acids

The ability to efficiently scavenge nutrients in the host is essential for the viability of any pathogen. All catabolic pathways must begin with the transport of substrate from the environment through the cytoplasmic membrane, a role executed by membrane transporters. Although several classes of cyt...