Dynamic Change in Insulin Resistance Induced by Free Fatty Acids Is Unchanged Though Insulin Sensitivity Improves Following Endurance Exercise in PCOS

• Published in: Frontiers in endocrinology (Lausanne) Vol. 9; p. 592
• Main Authors: Aye, Myint Myint, Butler, Alexandra E, Kilpatrick, Eric S, Kirk, Richard, Vince, Rebecca, Rigby, Alan S, Sandeman, Derek, Atkin, Stephen L
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.10.2018
• Subjects: Endocrinology; endurance exercise; insulin resistance; insulin sensitivity; intralipid; PCOS; insulin sensitivity; PCOS; endurance exercise; insulin resistance; intralipid

Insulin resistance (IR) is the hallmark of PCOS and it is known that exercise may decrease it. What is unknown is whether exercise may mechanistically alter the underlying IR, attenuating the dynamic lipid induced IR in insulin resistant subjects. 12 women with polycystic ovary syndrome (PCOS) and 1...