Influence of ADAM10 Polymorphisms on Plasma Level of Soluble Receptor for Advanced Glycation End Products and The Association With Alzheimer’s Disease Risk

• Published in: Frontiers in genetics Vol. 9; p. 540
• Main Authors: Huang, Wen-Hui, Chen, Wei, Jiang, Lian-ying, Yang, Yi-Xia, Yao, Li-Fen, Li, Ke-Shen
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 13.11.2018
• Subjects: ADAM10; Alzheimer’s disease; Genetics; RAGE; single nucleotide polymorphism (SNP); soluble receptor for advanced glycation end products; ADAM10; RAGE; Alzheimer’s disease; soluble receptor for advanced glycation end products; single nucleotide polymorphism (SNP)

To determine the role of A disintegrin and metalloproteinase 10 (ADAM10) in genetic susceptibility to Alzheimer's disease (AD) in a representative Chinese sample, we genotyped 362 AD patients and 370 healthy controls for the rs514049A/C and rs653765C/T polymorphisms in the ADAM10 promoter using...