Modulation of Immune Responses by Platelet-Derived ADAM10

• Published in: Frontiers in immunology Vol. 11; p. 44
• Main Authors: Maurer, Stefanie, Kopp, Hans-Georg, Salih, Helmut R, Kropp, Korbinian N
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 05.02.2020
• Subjects: ADAM10; ADAM10 Protein - metabolism; Amyloid Precursor Protein Secretases - metabolism; Animals; Blood Platelets - immunology; ectodomain shedding; Humans; immune evasion; Immunity; Immunology; Matrix Metalloproteinases - metabolism; Membrane Proteins - metabolism; Mice; Neoplasms - immunology; Neoplasms - metabolism; platelets; Proteolysis; tumor; Tumor Escape; ADAM10; ectodomain shedding; immune evasion; tumor; platelets

Platelets have a crucial function in maintaining hemostasis. However, beyond their role in coagulation and thrombus formation, platelets have been implicated to affect various pathophysiological conditions such as infectious diseases, autoimmune disorders, and cancer. It is well-established that pla...