Kite Proteins: a Superfamily of SMC/Kleisin Partners Conserved Across Bacteria, Archaea, and Eukaryotes

• Published in: Structure (London) Vol. 23; no. 12; pp. 2183 - 2190
• Main Authors: Palecek, Jan J., Gruber, Stephan
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.12.2015
• Subjects: Amino Acid Sequence; Archaeal Proteins - chemistry; Archaeal Proteins - genetics; Archaeal Proteins - metabolism; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Cell Cycle Proteins - chemistry; Cell Cycle Proteins - genetics; Cell Cycle Proteins - metabolism; chromosome segregation; cohesin; cohesion; condensation; condensin; Conserved Sequence; Kinesin - chemistry; Kinesin - metabolism; kite proteins; kleisin; MAGE; MksBEF; Molecular Sequence Data; MukBEF; replication; SMC; Smc/ScpAB; Smc5/6; structural maintenance of chromosomes; winged helix domains; replication; condensin; Smc5/6; MukBEF; SMC; kite proteins; MksBEF; MAGE; cohesin; chromosome segregation; kleisin; Smc/ScpAB; structural maintenance of chromosomes; condensation; cohesion; winged helix domains

SMC/kleisin complexes form elongated annular structures, which are critical for chromosome segregation, genome maintenance, and the regulation of gene expression. We describe marked structural similarities between bacterial and eukaryotic SMC/kleisin partner proteins (designated here as “kite” prote...