Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?

• Published in: Frontiers in immunology Vol. 9; p. 2622
• Main Authors: Thompson, Cherrie D, Matta, Bharati, Barnes, Betsy J
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 20.11.2018
• Subjects: autoimmunity; Immunology; inhibition; IRF5; negative regulation; positive regulation; negative regulation; inhibition; IRF5; positive regulation; autoimmunity

The interferon regulatory factors (IRFs) are a family of master transcription factors that regulate pathogen-induced innate and acquired immune responses. Aberration(s) in IRF signaling pathways due to infection, genetic predisposition and/or mutation, which can lead to increased expression of type...