How many single-nucleotide polymorphisms (SNPs) must be tested in order to prove susceptibility to bacterial meningitis in children? Analysis of 11 SNPs in seven genes involved in the immune response and their effect on the susceptibility to bacterial meningitis in children

• Published in: Innate immunity (London, England) Vol. 24; no. 3; pp. 163 - 170
• Main Authors: Gowin, Ewelina, Świątek-Kościelna, Bogna, Kałużna, Ewelina, Strauss, Ewa, Wysocki, Jacek, Nowak, Jerzy, Michalak, Michał, Januszkiewicz-Lewandowska, Danuta
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.04.2018; SAGE PUBLICATIONS, INC
• Subjects: Alleles; Bacteria; Child; Children; DNA - genetics; Gene Frequency; Genetic factors; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Immune response; Immunity, Innate - genetics; Meningitis; Meningitis, Bacterial - epidemiology; Meningitis, Bacterial - genetics; Meningitis, Bacterial - immunology; Original; Poland - epidemiology; Polymorphism, Single Nucleotide - genetics; Prospective Studies; Single-nucleotide polymorphism; Statistical analysis; Susceptibility; Vaccines; Poland; meningococci; Complement; pneumococci; innate immunity; meningitis

The aim of this study is to describe the prevalence of single single-nucleotide polymorphisms (SNPs) as well as their combinations in genes encoding proteins involved in the immune response in children with bacterial meningitis. The prospective study group consisted of 39 children with bacterial men...