Differential Cytokine Utilization and Tissue Tropism Results in Distinct Repopulation Kinetics of Naïve vs. Memory T Cells in Mice

• Published in: Frontiers in immunology Vol. 10; p. 355
• Main Authors: Kim, Hye Kyung, Chung, Hyunsoo, Kwon, Juntae, Castro, Ehydel, Johns, Christopher, Hawk, Nga V, Hwang, SuJin, Park, Jung-Hyun, Gress, Ronald E
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 04.03.2019
• Subjects: Adoptive Transfer - methods; Animals; apoptosis; Cell Survival - immunology; cytokines; Cytokines - immunology; Homeostasis - immunology; Immunologic Memory - immunology; Immunology; Interleukin-15 - immunology; Kinetics; Lymphocyte Activation - immunology; lymphopenia; Lymphopenia - immunology; Mice; Mice, Inbred C57BL; migration; proliferation; Receptors, Interleukin-7 - immunology; Signal Transduction - immunology; STAT5 Transcription Factor - immunology; migration; apoptosis; cytokines; proliferation; lymphopenia

Naïve and memory T cells co-exist in the peripheral T cell pool, but the cellular mechanisms that maintain the balance and homeostasis of these two populations remain mostly unclear. To address this question, here, we assessed homeostatic proliferation and repopulation kinetics of adoptively transfe...