Incidence of heparin-PF4 complex antibody formation and heparin-induced thrombocytopenia in acute coronary syndrome

• Published in: Thrombosis research Vol. 115; no. 6; pp. 475 - 481
• Main Authors: Matsuo, Takefumi, Tomaru, Takanobu, Kario, Kazuomi, Hirokawa, Takeshi
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 2005; Elsevier Science
• Subjects: Acute coronary syndrome; Acute Disease; Aged; Angioplasty, Balloon, Coronary; Antibodies - blood; Biological and medical sciences; Blood and lymphatic vessels; Blood. Blood coagulation. Reticuloendothelial system; Cardiology. Vascular system; Cohort Studies; Coronary Disease - blood; Coronary Disease - immunology; Coronary Disease - therapy; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Drug toxicity and drugs side effects treatment; Female; Heparin; Heparin - adverse effects; Heparin - immunology; Heparin-induced thrombocytopenia; Humans; Japan; Male; Medical sciences; Odds Ratio; Percutaneous coronary intervention; Pharmacology. Drug treatments; Platelet Count; Platelet Factor 4 - immunology; Prospective Studies; Regression Analysis; Serologic Tests; Syndrome; Thrombocytopenia - chemically induced; Thrombocytopenia - drug therapy; Thrombocytopenia - immunology; Toxicity: blood; Treatment Outcome; Japan; Percutaneous coronary intervention; Heparin; Acute coronary syndrome; Heparin-induced thrombocytopenia; Endocrinopathy; Myocardial infarction; Multicenter study; Cardiovascular disease; Lipids; Hemopathy; Anticoagulant; Myocardial disease; Mechanical factor; Incidence; Percutaneous route; Vascular disease; Complication; Hyperlipemia; Dyslipemia; Thromboembolism; Human; Thrombocytopenia; Diabetes mellitus; Metabolic diseases; Coronary heart disease; Japanese; Thrombosis; Embolism; Platelet; Treatment; Risk factor; Glycosaminoglycan; Variant angina

A multicenter prospective study on the rate of seroconversion of antibodies to heparin-PF4 complexes (heparin-induced thrombocytopenia [HIT] antibodies) during and after heparin treatment for 4 weeks was carried out in Japanese patients with acute coronary syndrome (ACS). A total of 254 ACS patients...