Syntheses of Mercaptobenzoic Acids and Mercaptopyridines Using Elemental Sulfur in the Presence of NaOH-KOH

Mercaptobenzoic acids and mercaptopyridines were synthesized by using mercaptylation of halogeno compounds with elemental sulfur in the presence of molten salts (NaOH-KOH). This procedure was also applied to the preparation of selenoaryl compounds by using elemental selenium. Based on the behavior o...

Full description

Saved in:
Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 33; no. 12; pp. 5184 - 5189
Main Authors KAMIYAMA, TSUTOMU, ENOMOTO, SABURO, INOUE, MASAMI
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1985
Maruzen
Japan Science and Technology Agency
Subjects
2-mercaptopyridine
Chemistry
Exact sciences and technology
Noncondensed benzenic compounds
Organic chemistry
Preparations and properties
Organic selenide
Selenol
Nitrogen heterocycle
Mercaptoacid
Organic sulfide
Thiolation
Molten salt
Potassium Hydroxides
Carboxylic acid
Medium effect
Sodium Hydroxides
Chlorine Organic compounds
Six membered ring
Benzenic compound
Methylation
Aromatic substitution
Online AccessGet full text

Cover

More Information
Summary:Mercaptobenzoic acids and mercaptopyridines were synthesized by using mercaptylation of halogeno compounds with elemental sulfur in the presence of molten salts (NaOH-KOH). This procedure was also applied to the preparation of selenoaryl compounds by using elemental selenium. Based on the behavior of the molten salts and sulfur, Na2S and K2S were considered to be the active species for the mercaptylation.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.33.5184