The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Published in: Frontiers in pharmacology Vol. 4; p. 165
• Main Authors: Steiner, Michel A, Sciarretta, Carla, Pasquali, Anne, Jenck, Francois
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 01.01.2013
• Subjects: diet-induced obesity; food intake; food preference; Lipid Metabolism; metabolic syndrome; orexin; Pharmacology; metabolic syndrome; food preference; lipid metabolism; ACT-335827; orexin; orexin receptor antagonist; diet-induced obesity; food intake

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...