Mitochondrial H2O2 release does not directly cause damage to chromosomal DNA

• Published in: Nature communications Vol. 15; no. 1; p. 2725
• Main Authors: van Soest, Daan M. K., Polderman, Paulien E., den Toom, Wytze T. F., Keijer, Janneke P., van Roosmalen, Markus J., Leyten, Tim M. F., Lehmann, Johannes, Zwakenberg, Susan, De Henau, Sasha, van Boxtel, Ruben, Burgering, Boudewijn M. T., Dansen, Tobias B.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 28.03.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 13/95; 14/19; 45/23; 631/337/1427/2566; 631/80/86/2366; 82/1; 96/35; 96/63; Aging; Cancer; Cell cycle; Damage localization; Deoxyribonucleic acid; DNA; DNA damage; Humanities and Social Sciences; Hydrogen peroxide; Mitochondria; Mitochondrial DNA; multidisciplinary; Mutation; Nucleosomes; Reactive oxygen species; Science; Science (multidisciplinary)

Reactive Oxygen Species (ROS) derived from mitochondrial respiration are frequently cited as a major source of chromosomal DNA mutations that contribute to cancer development and aging. However, experimental evidence showing that ROS released by mitochondria can directly damage nuclear DNA is largel...