Synergistic antitumor efficacy of aspirin plus lenvatinib in hepatocellular carcinoma via regulating of diverse signaling pathways

• Published in: Cell death discovery Vol. 9; no. 1; pp. 416 - 11
• Main Authors: Yan, Xijing, Yu, Haoyuan, Liang, Jinliang, Hu, Zhongying, Li, Xuejiao, Liu, Huanyi, Yao, Jia, Sui, Xin, Zheng, Jun, Li, Rong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.11.2023; Springer Nature B.V; Nature Publishing Group
• Subjects: 631/67/1059/153; 692/308/2778; Antitumor activity; Apoptosis; Aspirin; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Cycle Analysis; Clinical trials; Hepatocellular carcinoma; Life Sciences; Liver cancer; Signal transduction; Stem Cells

It has been established that monotherapy yields limited efficacy in treating hepatocellular carcinoma (HCC), especially advanced HCC. Increasing evidence from preclinical studies and clinical trials indicates that combining multiple drugs can potentially refine treatment efficacy. Accordingly, it is...