Inhibitory Receptors Beyond T Cell Exhaustion

• Published in: Frontiers in immunology Vol. 6; p. 310
• Main Authors: Fuertes Marraco, Silvia A, Neubert, Natalie J, Verdeil, Grégory, Speiser, Daniel E
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 26.06.2015
• Subjects: activation; differentiation; immune monitoring; Immunology; Immunotherapy; inhibitory receptors; t cell exhaustion; checkpoint blockade; differentiation; immunotherapy; inhibitory receptors; T cell exhaustion; immune monitoring; activation

Inhibitory receptors (iRs) are frequently associated with "T cell exhaustion". However, the expression of iRs is also dependent on T cell differentiation and activation. Therapeutic blockade of various iRs, also referred to as "checkpoint blockade", is showing -unprecedented resu...